Find hotels in Southeast Missouri, MO from ₩88,759
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Check prices for these dates
Tonight
Aug 17 - Aug 18Tomorrow
Aug 18 - Aug 19This weekend
Aug 21 - Aug 23Next weekend
Aug 28 - Aug 30Our top choices for Southeast Missouri hotels
1. Perryville RV Resort
Perryville RV ResortPerryville
Von
₩94,001
₩107,608 total
includes taxes & fees
Aug 18 - Aug 19
2. Holiday Inn Express & Suites Perryville by IHG
Holiday Inn Express & Suites Perryville by IHGPerryville
Jacalyn
₩137,321
₩157,199 total
includes taxes & fees
Sep 6 - Sep 7
3. Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
JoAnn
₩141,554
₩159,692 total
includes taxes & fees
Aug 23 - Aug 24
4. Crown Pointe Lodge, BW Signature Collection
Crown Pointe Lodge, BW Signature CollectionFarmington
Louise
₩144,399
₩157,179 total
includes taxes & fees
Aug 30 - Aug 31
5. Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
Sally
₩133,060
₩152,985 total
includes taxes & fees
Aug 23 - Aug 24
6. The Riverview
The RiverviewCape Girardeau
James
₩161,812
₩182,538 total
includes taxes & fees
Aug 18 - Aug 19
7. Super 8 by Wyndham Farmington
Super 8 by Wyndham FarmingtonFarmington
Saundra
₩84,233
₩91,688 total
includes taxes & fees
Aug 30 - Aug 31
8. Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
Joni
₩155,725
₩176,320 total
includes taxes & fees
Aug 27 - Aug 28
9. Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau WestCape Girardeau
Bonnie
₩101,915
₩114,975 total
includes taxes & fees
Aug 23 - Aug 24
10. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
Kevin
₩119,129
₩128,927 total
includes taxes & fees
Aug 18 - Aug 19
11. Honeysuckle Inn - Mountain View
Honeysuckle Inn - Mountain ViewMountain View
JOAQUIN
₩140,152
₩151,945 total
includes taxes & fees
Aug 19 - Aug 20
12. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
ELAINE
₩155,725
₩175,679 total
includes taxes & fees
Aug 20 - Aug 21
13. Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MOFarmington
Kellie
₩81,543
₩88,759 total
includes taxes & fees
Aug 31 - Sep 1
14. Comfort Suites Jackson-Cape Girardeau
Comfort Suites Jackson-Cape GirardeauJackson
VICTORIA
₩118,665
₩128,416 total
includes taxes & fees
Sep 15 - Sep 16
15. Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
Jamie
₩113,240
₩119,723 total
includes taxes & fees
Aug 23 - Aug 24
16. Hampton Inn Sikeston
Hampton Inn SikestonSikeston
Brandi
₩138,142
₩156,411 total
includes taxes & fees
Aug 23 - Aug 24
17. Super 8 by Wyndham Potosi
Super 8 by Wyndham PotosiPotosi
Ross
₩82,421
₩90,023 total
includes taxes & fees
Aug 23 - Aug 24
18. The Farmstead Hotel
The Farmstead HotelCaruthersville
Mary
₩110,423
₩125,585 total
includes taxes & fees
Aug 22 - Aug 23
19. Courtyard by Marriott Cape Girardeau Downtown
Courtyard by Marriott Cape Girardeau DowntownCape Girardeau
Taylor
₩177,102
₩200,680 total
includes taxes & fees
Aug 30 - Aug 31
20. La Quinta Inn & Suites by Wyndham Festus - St. Louis South
La Quinta Inn & Suites by Wyndham Festus - St. Louis SouthFestus
Lisa-Marie
₩143,196
₩163,746 total
includes taxes & fees
Aug 20 - Aug 21
Vacation Rentals in Southeast Missouri
Cabin
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
"I really enjoyed my time at the stay !"
Aparthotel
The Atrium - A Boutique Hotel
The Atrium - A Boutique HotelPerryville
"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."
Cottage
'turtle Rock' - Ironton Cabin w/ Furnished Patio!
'turtle Rock' - Ironton Cabin w/ Furnished Patio!Ironton
"Stroller, pack n play and high chair. This was amazing "
Vacation Home
Tiny Houses of French Village
Tiny Houses of French VillageFrench Village
"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "
Cottage
Walk to Dtwn: Ironton Home in Historic District
Walk to Dtwn: Ironton Home in Historic DistrictIronton
"Clean and comfortable "
Cottage
40-acre Poplar Bluff Nature Lovers Paradise!
40-acre Poplar Bluff Nature Lovers Paradise!Poplar Bluff
"Beautiful place enjoyed our stay"
Cottage
Cozy Belgrade Cottage w/ Wood-burning Stove!
Cozy Belgrade Cottage w/ Wood-burning Stove!Belgrade
Cottage
Cottage w/ Yard, Walk to Historic Attractions
Cottage w/ Yard, Walk to Historic AttractionsSte Genevieve
"The little blue cottage was very comfortable, clean and close to everything downtown. We parked the car and walked everywhere. It was on a quiet street. The bed was comfy, clean kitchen. We liked the little back yard, for relaxing. "
Cottage
Walk to Current River: Ozarks Adventure Home!
Walk to Current River: Ozarks Adventure Home!Van Buren
"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."
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Stay near popular Southeast Missouri attractions
Photo by Pat Long
Elephant Rocks State Park
9.6/10 (98 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
Southeast Missouri State University
8.8/10 (248 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
Photo by JG Morris
Lake Wappapello
8.8/10 (54 reviews)
Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.
Century Casino & Hotel Cape Girardeau
8.4/10 (176 reviews)
Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.
Century Casino Caruthersville
7.0/10 (57 reviews)
Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants.
Learn more about Southeast Missouri
Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from Sam A. Baker State Park to K Bridge Recreation Area.
See all hotels in Southeast Missouri
Photo by Bill Dillard
Top Southeast Missouri Hotel Reviews
Drury Plaza Hotel Cape Girardeau Conference Center
10/10 Excellent
"Great room, great breakfast. Friendly, helpful staff."
Baymont Inn and Suites by Wyndham Farmington, MO
10/10 Excellent
"The staff were very helpful. The room was in good shape."
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
10/10 Excellent
"Excellent experience here. No complaints or concerns. Our travels in the next six weeks will include this hotel chain because of this experience!"
Drury Inn & Suites Sikeston, MO
10/10 Excellent
"very nice staff and good food"
Candlewood Suites Cape Girardeau by IHG
10/10 Excellent
"Property was clean a room was stocked. Had microwave refrigerator and a stove refrigerator had working ice maker. Great room for the price"
Comfort Inn Festus - St Louis South
10/10 Excellent
"I always choose to stay here when visiting family. This stay was as always a delight."
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
10/10 Excellent
"It was a very unique and great experience! Would definitely recommend to others."
More cheap stays in Southeast Missouri
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
₩81,543
₩88,759 total
Aug 31 - Sep 1
includes taxes & fees
8/10 Very Good! (1,008 reviews)
Comfort Inn Festus - St Louis South
1303 Veterans Blvd Festus MO
₩85,677
₩100,113 total
Sep 7 - Sep 8
includes taxes & fees
7.8/10 Good! (987 reviews)
Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr Sikeston MO
₩90,250
₩102,863 total
Sep 13 - Sep 14
includes taxes & fees
Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
₩111,839
₩125,245 total
Aug 22 - Aug 23
includes taxes & fees
The Farmstead Hotel
778 E 3rd St Caruthersville MO
₩110,423
₩125,585 total
Aug 22 - Aug 23
includes taxes & fees
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
3253 William Street Cape Girardeau MO
₩155,725
₩175,679 total
Aug 20 - Aug 21
includes taxes & fees
9.4/10 Exceptional! (1,004 reviews)
Hotels in Southeast Missouri with star-rating
4 Star Hotels
2 properties
3 Star Hotels
70 properties
2 Star Hotels
90 properties
