Our top choices for Southeast Missouri hotels

Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Jonna

₩173,126 total

includes taxes & fees

Jul 12 - Jul 13

Drury Inn & Suites Sikeston, MO

Sikeston

Jennifer

₩195,854 total

includes taxes & fees

Jul 16 - Jul 17

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Festus

Delos

₩207,091 total

includes taxes & fees

Jul 19 - Jul 20

The Riverview

Cape Girardeau

John

₩229,068 total

includes taxes & fees

Jun 30 - Jul 1

Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

Daisy

₩111,256 total

includes taxes & fees

Jul 5 - Jul 6

Perryville RV Resort

Perryville

₩129,625 total

includes taxes & fees

Jul 1 - Jul 2

Standard Room, 2 Queen Beds | In-room safe, desk, blackout drapes, iron/ironing board

Super 8 by Wyndham Potosi

Potosi

Julie

₩97,597 total

includes taxes & fees

Jul 7 - Jul 8

Crown Pointe Lodge, BW Signature Collection

Farmington

Colleen

₩183,180 total

includes taxes & fees

Jul 30 - Jul 31

Courtyard by Marriott Cape Girardeau Downtown

Cape Girardeau

Taylor

₩217,563 total

includes taxes & fees

Jul 12 - Jul 13

Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

Alice

₩175,124 total

includes taxes & fees

Jul 12 - Jul 13

Hampton Inn Poplar Bluff

Poplar Bluff

Tammy

₩167,698 total

includes taxes & fees

Jul 12 - Jul 13

Desk, laptop workspace, blackout drapes, iron/ironing board

Drury Inn & Suites Cape Girardeau

Cape Girardeau

Lee

₩164,470 total

includes taxes & fees

Jul 7 - Jul 8

Holiday Inn Express & Suites Perryville by IHG

Perryville

Cheryl

₩186,234 total

includes taxes & fees

Jul 30 - Jul 31

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

Sheldon

₩153,892 total

includes taxes & fees

Jul 1 - Jul 2

Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Joni

₩191,152 total

includes taxes & fees

Jul 12 - Jul 13

Honeysuckle Inn - Mountain View

Mountain View

Monica

₩164,727 total

includes taxes & fees

Jun 30 - Jul 1

Super 8 by Wyndham Farmington

Farmington

Sarah

₩108,256 total

includes taxes & fees

Jul 5 - Jul 6

Motel 6 Poplar Bluff, MO

Poplar Bluff

Morgan

₩135,781 total

includes taxes & fees

Jul 6 - Jul 7

Hampton Inn Sikeston

Sikeston

Brandi

₩190,840 total

includes taxes & fees

Jul 23 - Jul 24

Deerfield Inn & Suites Steele Near Blytheville I 55

Steele

₩85,441 total

includes taxes & fees

Jun 30 - Jul 1

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Vacation Rentals in Southeast Missouri

Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

"The Experience was amazing and we enjoyed the views and the firepit!"

Vacation Home

Tiny Houses of French Village

French Village

"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "

Aparthotel

The Atrium - A Boutique Hotel

Perryville

"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."

Cottage

Walk to Current River: Ozarks Adventure Home!

Van Buren

"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."

Cottage

Cozy Belgrade Cottage w/ Wood-burning Stove!

Belgrade

Cottage

Cottage w/ Yard, Walk to Historic Attractions

Ste Genevieve

"The little blue cottage was very comfortable, clean and close to everything downtown. We parked the car and walked everywhere. It was on a quiet street. The bed was comfy, clean kitchen. We liked the little back yard, for relaxing. "

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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/5 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

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Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from Walnut Hollow Lake to K Bridge Recreation Area.

See all hotels in Southeast Missouri

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.

Top Southeast Missouri Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent

"It was absolutely amazing"

Drury Inn & Suites Jackson MO

10/10 Excellent

"Could not have asked for a better experience! Staff was welcoming, very helpful, and super efficient. Pool and hot tub was very clean, temperature was great, and had ample towels and seating. Kickbacks was amazing!!!! We went to Iron Mountain Railroad, Trail of Tears State Park and Bollinger Grist Mill and Covered Bridge - all just a few minutes away. Easy location, gas station and Dairy Queen within walking distance. You’re missing out if you don’t stay here!!!"

Motel 6 Poplar Bluff, MO

10/10 Excellent

"Room was clean, staff were friendly. The bench in the gazebo was broke but we didn't use that area I just saw it. There were some loud guests with kids running around at midnight but that can happen at any hotel. My recommendation would be more than two pillows per bed. This is our second year staying here when we come to town for a conference and both times it was a good experience"