Photo by Bill Dillard

Find hotels in Southeast Missouri, MO from ₩90,969

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Nov 13 - Nov 14
Tomorrow
Nov 14 - Nov 15
This weekend
Nov 14 - Nov 16
Next weekend
Nov 21 - Nov 23

Filter by

Guest rating
Guest rating
Star rating

Compare 600 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Front of property
The Farmstead Hotel

The Farmstead Hotel

2.5 star property
Caruthersville
8.8 out of 10, Excellent, (444)
"Excellent hotel. Very clean."
United States
Don
The price is ₩125,581
₩142,817 total
includes taxes & fees
Nov 15 - Nov 16
The Farmstead Hotel
Exterior
Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG

2.5 star property
Perryville
9.2 out of 10, Wonderful, (529)
"Clean room and pleasant staff"
United States
David
The price is ₩139,534
₩159,732 total
includes taxes & fees
Nov 16 - Nov 17
Holiday Inn Express & Suites Perryville by IHG
Lobby
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1001)
"Staff very accommodating and everything was very clean!"
United States
Dericka
The price is ₩102,800
₩115,975 total
includes taxes & fees
Nov 17 - Nov 18
Pear Tree Inn Cape Girardeau West
Lobby
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

3.0 star property
Jackson
9.6 out of 10, Exceptional, (1003)
"Nice place"
United States
Daniel
The price is ₩129,238
₩136,641 total
includes taxes & fees
Nov 16 - Nov 17
Drury Inn & Suites Jackson MO
Exterior
Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington

2.0 star property
Farmington
8.0 out of 10, Very Good, (602)
"Clean, friendly staff, quiet"
United States
Stacy
The price is ₩74,908
₩85,283 total
includes taxes & fees
Nov 20 - Nov 21
Super 8 by Wyndham Farmington
Front of property
Echo Bluff State Park

Echo Bluff State Park

2.5 star property
Eminence
9.4 out of 10, Exceptional, (213)
"Very helpful staff member who helped me find a room that would accommodate my dog after booking"
United States
Jeremiah
The price is ₩233,536
₩246,906 total
includes taxes & fees
Nov 16 - Nov 17
Echo Bluff State Park
Standard Room, 1 King Bed | In-room safe, desk, blackout drapes, iron/ironing board
Super 8 by Wyndham Potosi

Super 8 by Wyndham Potosi

2.0 star property
Potosi
7.0 out of 10, Good, (374)
"I like how convenient everything was mangers were awesome All my needs were met and I look forward to visiting there again "
United States
Shirley
The price is ₩81,150
₩88,636 total
includes taxes & fees
Nov 16 - Nov 17
Super 8 by Wyndham Potosi
Property amenity
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3.0 star property
Jackson
8.8 out of 10, Excellent, (650)
"Stayed on our way south for vacation. It was a clean nice place to stay. "
United States
Joel
The price is ₩123,598
₩133,762 total
includes taxes & fees
Nov 15 - Nov 16
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1002)
"Clean room and amenities were great"
United States
Crystal
The price is ₩132,176
₩149,096 total
includes taxes & fees
Dec 1 - Dec 2
Drury Plaza Hotel Cape Girardeau Conference Center
Lobby
Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

3.0 star property
Hayti
9.4 out of 10, Exceptional, (1000)
"Great stay. Clean room, and Drury Inns always seem to have the most comfortable beds."
United States
Ted
The price is ₩138,051
₩157,336 total
includes taxes & fees
Nov 23 - Nov 24
Drury Inn & Suites Hayti Caruthersville
Free buffet breakfast
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

2.5 star property
Festus
9.4 out of 10, Exceptional, (693)
"Love staying at the holiday inn ans suites "
United States
Amber
The price is ₩179,191
₩204,905 total
includes taxes & fees
Nov 16 - Nov 17
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Business center
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 star property
Farmington
8.0 out of 10, Very Good, (1003)
"The room was clean and the staff, as always were very courteous!"
United States
Steven
The price is ₩79,902
₩90,969 total
includes taxes & fees
Nov 20 - Nov 21
Baymont Inn and Suites by Wyndham Farmington, MO
Lobby
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1001)
"Always enjoy our stay. Staff is very friendly, especially at breakfast! "
United States
Paul
The price is ₩102,800
₩115,975 total
includes taxes & fees
Nov 17 - Nov 18
Pear Tree Inn Cape Girardeau Near the Medical Center
Business center
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1000)
"Rooms are nice and big. Breakfast was above average and staff was very nice and friendly. "
United States
Sandra
The price is ₩132,176
₩149,096 total
includes taxes & fees
Nov 23 - Nov 24
Drury Inn & Suites Cape Girardeau
Exterior
Super 8 by Wyndham Perryville

Super 8 by Wyndham Perryville

2.0 star property
Perryville
8.4 out of 10, Very Good, (927)
"We had a nice stay and they were pet friendly! The front desk staff was very nice and welcoming. "
United States
Jacquelin
The price is ₩98,629
₩112,906 total
includes taxes & fees
Nov 30 - Dec 1
Super 8 by Wyndham Perryville
Breakfast, lunch, dinner served; Italian cuisine
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (685)
"I appreciated the quiet room, friendly staff and the included breakfast "
United States
ray
The price is ₩148,347
₩167,595 total
includes taxes & fees
Nov 23 - Nov 24
Holiday Inn Poplar Bluff by IHG
Meeting facility
Baymont by Wyndham Festus

Baymont by Wyndham Festus

3.0 star property
Festus
6.8 out of 10, (912)
"They was doing construction on The floor I was on . The had 10 Mexican people in the hallway drinking and partying. They refuse to give me my money back. "
United States
Keilen
The price is ₩118,384
₩135,371 total
includes taxes & fees
Dec 14 - Dec 15
Baymont by Wyndham Festus
Exterior
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 star property
Sikeston
8.8 out of 10, Excellent, (423)
"Nice property and friendly staff."
United States
Nancy
The price is ₩139,828
₩158,322 total
includes taxes & fees
Nov 30 - Dec 1
Hampton Inn Sikeston
Standard Double Room, 2 Queen Beds, Transfer Shower | Desk, laptop workspace, free WiFi
Century Casino & Hotel Caruthersville

Century Casino & Hotel Caruthersville

2.0 star property
Caruthersville
8.4 out of 10, Very Good, (91)
"Wonderful stay!!"
United States
Miguel
The price is ₩178,456
₩202,950 total
includes taxes & fees
Nov 15 - Nov 16
Century Casino & Hotel Caruthersville
Lobby sitting area
The Riverview

The Riverview

4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (450)
"Location was perfect for family weekend!"
United States
Kelly
The price is ₩141,443
₩159,566 total
includes taxes & fees
Nov 16 - Nov 17
The Riverview
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Great weekend hotel deals in Southeast Missouri, MO

Showing deals for:Nov 21 - Nov 23

Image gallery for Tiny Houses of French Village

House | Living area

Tiny Houses of French Village

2.5 star property
French Village
10/10Exceptional (3 reviews)
10% off
Price is ₩357,424
₩859,899 total
includes taxes & fees
Tiny Houses of French Village
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Check out hotels with a hot tub in Southeast Missouri

Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1002)
The price is ₩132,176
₩149,096 total
includes taxes & fees
Dec 1 - Dec 2
Drury Plaza Hotel Cape Girardeau Conference Center
View all properties

Family-friendly hotels in Southeast Missouri you'll enjoy

Property amenity
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3.0 star property
Jackson
8.8 out of 10, Excellent, (650)
The price is ₩123,598
₩133,762 total
includes taxes & fees
Nov 15 - Nov 16
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
View all properties

Hotels with free breakfast in Southeast Missouri may fit your trip

Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1002)
The price is ₩132,176
₩149,096 total
includes taxes & fees
Dec 1 - Dec 2
Drury Plaza Hotel Cape Girardeau Conference Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Stay near popular Central United States attractions

Panorama of Academic Hall, Southeast Missouri State University

Southeast Missouri State University

4.4/5 (137 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
See properties
A huge granite boulder located in Elephant Rocks State Park
Photo by Pat Long
Open Photo by Pat Long

Elephant Rocks State Park

4.8/5 (52 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
See properties

Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from Sam A. Baker State Park to K Bridge Recreation Area.

See all hotels in Southeast Missouri
Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg: Moark Regional Railroad Museum HOURS: Saturdays 1 p.m. - 4 p.m. It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history. This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! #MTTS2014 #minitakesthestates #go11 #train
Photo by Bill Dillard
Open Photo by Bill Dillard

Top Southeast Missouri Hotel Reviews

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

10/10 Excellent
"Everything about our stay was in complete order; access to room was easily located; office & staff were very accommodating & room was very clean & orderly. If it is necessary to have a stay in Poplar Bluff, MO at some given time; this will be our place to stay. Thank you for inquiring, good job!!!!"
Härryette 2-night trip
Posted 2 days ago
Motel 6 Poplar Bluff, MO

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St, Farmington, MO
The price is ₩79,902 per night from Nov 20 to Nov 21
₩79,902
₩90,969 total
Nov 20 - Nov 21
includes taxes & fees
8/10 Very Good! (1,002 reviews)

Hotels in Southeast Missouri with star-rating

Explore a world of travel with Expedia