Find hotels in Southeast Missouri, MO from ₩85,237

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Compare 604 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Our top choices for Southeast Missouri hotels

Drury Plaza Hotel Cape Girardeau Conference Center
Lobby

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
9.6 out of 10, Exceptional, (1014)
"Very nice hotel and nice staff "
The price is ₩125,698
₩141,789 total
includes taxes & fees
Oct 2 - Oct 3
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Inn & Suites Jackson MO
Lobby

Drury Inn & Suites Jackson MO

3.0 star property
9.6 out of 10, Exceptional, (1012)
"Was a clean room, nice staff, good parking "
The price is ₩125,698
₩132,892 total
includes taxes & fees
Sep 24 - Sep 25
Drury Inn & Suites Jackson MO
Drury Inn & Suites Cape Girardeau
Business center

Drury Inn & Suites Cape Girardeau

3.0 star property
9.4 out of 10, Exceptional, (996)
"Excellent place. Really friendly staff"
The price is ₩125,698
₩141,789 total
includes taxes & fees
Sep 28 - Sep 29
Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Sikeston, MO
Property amenity

Drury Inn & Suites Sikeston, MO

3.0 star property
9.4 out of 10, Exceptional, (1006)
"The pool the happy hour was really nice very relaxed nice activities front desk was very helpful at all times"
The price is ₩125,698
₩144,513 total
includes taxes & fees
Sep 25 - Sep 26
Drury Inn & Suites Sikeston, MO
EC Reed's Mercantile and Hotel
Deluxe Double Room | Premium bedding, individually decorated, individually furnished

EC Reed's Mercantile and Hotel

3.0 star property
9.6 out of 10, Exceptional, (77)
"Great, clean room and the restaurant attached was delicious- best breakfast! "
The price is ₩146,857
₩159,854 total
includes taxes & fees
Sep 22 - Sep 23
EC Reed's Mercantile and Hotel
Drury Inn & Suites Hayti Caruthersville
Lobby

Drury Inn & Suites Hayti Caruthersville

3.0 star property
9.4 out of 10, Exceptional, (1004)
"Nice place for a over night stay would recamend."
The price is ₩131,285
₩149,625 total
includes taxes & fees
Sep 28 - Sep 29
Drury Inn & Suites Hayti Caruthersville
Courtyard by Marriott Cape Girardeau Downtown
Lobby lounge

Courtyard by Marriott Cape Girardeau Downtown

3.0 star property
9.6 out of 10, Exceptional, (448)
"The Staff was friendly The restaurant was good"
The price is ₩174,600
₩197,846 total
includes taxes & fees
Oct 5 - Oct 6
Courtyard by Marriott Cape Girardeau Downtown
Pear Tree Inn Sikeston
Lobby

Pear Tree Inn Sikeston

2.5 star property
9.4 out of 10, Exceptional, (1003)
"I love this hotel! Have stayed several times and will definitely stay again. The rooms are always very clean and the staff is so friendly and helpful. I highly recommend this hotel!"
The price is ₩107,540
₩123,617 total
includes taxes & fees
Sep 24 - Sep 25
Pear Tree Inn Sikeston
Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
Exterior

Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG

3.5 star property
9.4 out of 10, Exceptional, (153)
"Enjoyed our short stay, will definitely be back. "
The price is ₩222,091
₩255,966 total
includes taxes & fees
Sep 21 - Sep 22
Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
Drury Inn & Suites Poplar Bluff
Lobby

Drury Inn & Suites Poplar Bluff

3.0 star property
9.2 out of 10, Wonderful, (911)
"Always a good stay"
The price is ₩131,285
₩148,298 total
includes taxes & fees
Sep 28 - Sep 29
Drury Inn & Suites Poplar Bluff
Holiday Inn Express & Suites Perryville by IHG
Exterior

Holiday Inn Express & Suites Perryville by IHG

2.5 star property
9.4 out of 10, Exceptional, (505)
"Have stayed here the past 3 years during the Laid Back on I-55 Truck Show! Great place to stay! The breakfast is fantastic!! The staff does not disappoint!! "
The price is ₩118,728
₩135,914 total
includes taxes & fees
Sep 28 - Sep 29
Holiday Inn Express & Suites Perryville by IHG
Tru By Hilton Cape Girardeau
Room, 2 Queen Beds

Tru By Hilton Cape Girardeau

2.5 star property
9.6 out of 10, Exceptional, (58)
"Great overall stay"
The price is ₩141,286
₩160,803 total
includes taxes & fees
Sep 28 - Sep 29
Tru By Hilton Cape Girardeau
Fairfield Inn & Suites by Marriott Cape Girardeau
Lobby lounge

Fairfield Inn & Suites by Marriott Cape Girardeau

2.5 star property
9.4 out of 10, Exceptional, (128)
"The hotel was very clean and updated and the staff was super friendly and very informative!"
The price is ₩129,902
₩146,547 total
includes taxes & fees
Sep 28 - Sep 29
Fairfield Inn & Suites by Marriott Cape Girardeau
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Exterior

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
9.4 out of 10, Exceptional, (1008)
"It was right off the interstate with lots of restaurant options "
The price is ₩132,696
₩149,701 total
includes taxes & fees
Oct 19 - Oct 20
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Pear Tree Inn Cape Girardeau West
Lobby

Pear Tree Inn Cape Girardeau West

2.5 star property
9.0 out of 10, Wonderful, (1005)
"My room was clean and I was very close to shopping and restaurants. I really enjoyed my stay there."
The price is ₩97,762
₩110,291 total
includes taxes & fees
Sep 21 - Sep 22
Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau Near the Medical Center
Lobby

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
9.0 out of 10, Wonderful, (1005)
"Excellent place to stay "
The price is ₩97,762
₩110,291 total
includes taxes & fees
Sep 25 - Sep 26
Pear Tree Inn Cape Girardeau Near the Medical Center
Hampton Inn Poplar Bluff
Terrace/patio

Hampton Inn Poplar Bluff

2.5 star property
9.4 out of 10, Exceptional, (762)
"The room was clean, the staff were nice and breakfast bar was good "
The price is ₩135,350
₩151,559 total
includes taxes & fees
Sep 28 - Sep 29
Hampton Inn Poplar Bluff
Fairfield Inn & Suites by Marriott Sikeston
Bar (on property)

Fairfield Inn & Suites by Marriott Sikeston

2.5 star property
9.4 out of 10, Exceptional, (23)
"Hotel was clean, the toilets could use some attention, but staff was friendly and the breakfast was good"
The price is ₩141,077
₩159,734 total
includes taxes & fees
Sep 28 - Sep 29
Fairfield Inn & Suites by Marriott Sikeston
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Property amenity

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3.0 star property
8.8 out of 10, Excellent, (620)
"Excellent place to stay. Breakfast was good and staff was friendly. "
The price is ₩117,541
₩127,208 total
includes taxes & fees
Sep 22 - Sep 23
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Hampton Inn Cape Girardeau I 55 East
Courtyard

Hampton Inn Cape Girardeau I 55 East

2.5 star property
9.6 out of 10, Exceptional, (747)
"Would prefer onsite restaurant and bar"
The price is ₩153,159
₩172,786 total
includes taxes & fees
Sep 28 - Sep 29
Hampton Inn Cape Girardeau I 55 East
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Great weekend hotel deals in Southeast Missouri, MO

Showing deals for:Oct 3 - Oct 5

Image gallery for Tiny Houses of French Village

House | Living area

Tiny Houses of French Village

2.5 star property
French Village
10/10Exceptional (3 reviews)
10% off
Price is ₩339,422
₩796,227 total
includes taxes & fees
Tiny Houses of French Village
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Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from Sam A. Baker State Park to K Bridge Recreation Area.

See all hotels in Southeast Missouri

Top Southeast Missouri Hotel Reviews

The Farmstead Hotel

The Farmstead Hotel

10/10 Excellent
"My stay was excellent. The hotel was clean, comfortable, and well-maintained, but what stood out most was the staff. They were attentive, welcoming, and went out of their way to make me feel at home. Truly outstanding service"
Edmund 2-night trip
Posted 23 hours ago
The Farmstead Hotel

More cheap stays in Southeast Missouri

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St, Farmington, MO
The price is ₩74,868 per night from Oct 14 to Oct 15
₩74,868
₩85,237 total
Oct 14 - Oct 15
includes taxes & fees
8/10 Very Good! (1,012 reviews)

Hotels in Southeast Missouri with star-rating

Hotels in Southeast Missouri with star-rating

Explore a world of travel with Expedia

Explore a world of travel with Expedia