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Find hotels in Defiance, MO from ₩98,842

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Compare 833 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3.0 star property
8.2 out of 10, Very Good, (1010)
"Clean room and staff was great "
The price is ₩120,206
₩138,845 total
includes taxes & fees
Nov 2 - Nov 3
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

The Wildwood Hotel

3.5 star property
9.2 out of 10, Wonderful, (1586)
"We enjoyed our stay!"
The price is ₩124,731
₩150,824 total
includes taxes & fees
Oct 13 - Oct 14
The Wildwood Hotel

Sonesta ES Suites St. Louis - Chesterfield

3.0 star property
8.0 out of 10, Very Good, (1002)
"Very nice place"
The price is ₩123,034
₩142,706 total
includes taxes & fees
Oct 14 - Oct 15
Sonesta ES Suites St. Louis - Chesterfield

Baymont by Wyndham Warrenton

2.5 star property
7.4 out of 10, Good, (1004)
"Welcoming staff, quiet hallwats, clise and convenient to amenities. "
The price is ₩122,186
₩140,189 total
includes taxes & fees
Oct 19 - Oct 20
Baymont by Wyndham Warrenton

Super 8 by Wyndham Eureka/Six Flags Nearby

2.0 star property
7.0 out of 10, Good, (1005)
"Clean room."
The price is ₩84,851
₩98,842 total
includes taxes & fees
Oct 21 - Oct 22
Super 8 by Wyndham Eureka/Six Flags Nearby

Best Western Plus St. Louis West-Westport

2.5 star property
8.0 out of 10, Very Good, (1003)
"It was a very nice place"
The price is ₩124,732
₩144,674 total
includes taxes & fees
Oct 19 - Oct 20
Best Western Plus St. Louis West-Westport

Hollywood Casino & Hotel St. Louis

3.5 star property
8.4 out of 10, Very Good, (2159)
"Always our favorite place to stay!"
The price is ₩124,435
₩165,644 total
includes taxes & fees
Oct 19 - Oct 20
Hollywood Casino & Hotel St. Louis

Sleep Inn & Suites O'Fallon MO - Technology Drive

2.5 star property
8.8 out of 10, Excellent, (1007)
"Great hotel! "
The price is ₩123,459
₩145,622 total
includes taxes & fees
Oct 13 - Oct 14
Sleep Inn & Suites O'Fallon MO - Technology Drive

Days Inn by Wyndham St Peters/St Charles

2.0 star property
6.4 out of 10, (994)
"Staff was very friendly. Room was kept clean."
The price is ₩102,175
₩117,452 total
includes taxes & fees
Oct 19 - Oct 20
Days Inn by Wyndham St Peters/St Charles

Best Western Plus Washington Hotel

2.5 star property
9.0 out of 10, Wonderful, (607)
"Clean and welcoming - great staff"
The price is ₩182,431
₩207,697 total
includes taxes & fees
Oct 12 - Oct 13
Best Western Plus Washington Hotel

Holiday Inn Express & Suites Wentzville St Louis West by IHG

2.5 star property
9.4 out of 10, Exceptional, (803)
"The area around the hotel appeared to be safe and well kept. "
The price is ₩196,855
₩234,339 total
includes taxes & fees
Oct 26 - Oct 27
Holiday Inn Express & Suites Wentzville St Louis West by IHG

AC Hotel by Marriott St. Louis Chesterfield

3.5 star property
9.2 out of 10, Wonderful, (208)
"Loved my stay here "
The price is ₩209,159
₩242,599 total
includes taxes & fees
Nov 2 - Nov 3
AC Hotel by Marriott St. Louis Chesterfield

Holiday Inn Express St. Louis West - O'Fallon by IHG

2.5 star property
8.6 out of 10, Excellent, (793)
"The staff were very nice & the breakfast was enjoyable. The hotel was clean."
The price is ₩134,348
₩158,464 total
includes taxes & fees
Oct 19 - Oct 20
Holiday Inn Express St. Louis West - O'Fallon by IHG

Drury Plaza Hotel St. Louis St. Charles

3.0 star property
9.6 out of 10, Exceptional, (1005)
"Clean, friendly staff and great amenities"
The price is ₩155,547
₩180,324 total
includes taxes & fees
Oct 12 - Oct 13
Drury Plaza Hotel St. Louis St. Charles

Comfort Inn & Suites St. Louis - O'Fallon

2.5 star property
7.6 out of 10, Good, (1005)
"And nice hotel at a nice price "
The price is ₩109,388
₩129,022 total
includes taxes & fees
Oct 26 - Oct 27
Comfort Inn & Suites St. Louis - O'Fallon

Hampton Inn St. Charles St. Peters

2.5 star property
8.0 out of 10, Very Good, (1004)
"All around good hotel"
The price is ₩128,338
₩147,494 total
includes taxes & fees
Oct 26 - Oct 27
Hampton Inn St. Charles St. Peters

Super 8 by Wyndham St Charles

2.0 star property
8.0 out of 10, Very Good, (1002)
"Was a good stay"
The price is ₩106,983
₩122,954 total
includes taxes & fees
Oct 14 - Oct 15
Super 8 by Wyndham St Charles

Elimwood Hotel, a Ramada by Wyndham

3.0 star property
7.4 out of 10, Good, (1003)
"Clean room friendly staff very helpful would definitely stay again "
The price is ₩123,458
₩143,195 total
includes taxes & fees
Oct 26 - Oct 27
Elimwood Hotel, a Ramada by Wyndham

Wingate by Wyndham St. Louis/Fenton Route 66

3.0 star property
8.0 out of 10, Very Good, (1039)
"Nice staff "
The price is ₩111,792
₩129,106 total
includes taxes & fees
Nov 2 - Nov 3
Wingate by Wyndham St. Louis/Fenton Route 66

La Quinta Inn & Suites by Wyndham St. Louis Westport

3.0 star property
7.2 out of 10, Good, (1062)
"Was a great stay "
The price is ₩131,095
₩152,053 total
includes taxes & fees
Oct 12 - Oct 13
La Quinta Inn & Suites by Wyndham St. Louis Westport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

Top Defiance Hotel Reviews

More cheap stays in Defiance

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Frequently asked questions

What's the best place to stay in Defiance?

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham, located 17.9 mi (28.8 km) from the heart of Defiance, is a top choice for your stay based on our traveler data. Other good choices for your stay in the area are Hollywood Casino & Hotel St. Louis and La Quinta Inn & Suites by Wyndham St. Louis Westport. See all available top hotels, or vacation rentals in Defiance.

If I need to cancel my hotel reservation in Defiance, will I receive a refund?

Yes, the majority of hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a reservation that's non-refundable, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.

Where can I learn more about changing or cancelling my trip to Defiance?

For more information about changing or cancelling your trip to Defiance, head over to our customer service page.

Where is the best hotel to stay with easy access to August A. Busch Memorial Conservation Area?

Sleep Inn & Suites O'Fallon MO - Technology Drive is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located 2.6 mi (4.3 km) from August A. Busch Memorial Conservation Area. Other good options within a few miles include Hilton Garden Inn St. Louis/O'Fallon MO and Holiday Inn Express St. Louis West - O'Fallon, an IHG Hotel.

What about the best place to stay near Chandler Hill Vineyards?

One of the top choices for your stay is The Wildwood Hotel, located 10 mi (16.1 km) from Chandler Hill Vineyards, and this 3.5-star hotel offers free breakfast and an indoor pool.

What are some accommodations with pools in Defiance?

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham: Features an indoor pool, an outdoor pool, and buffet. La Quinta Inn & Suites by Wyndham St. Louis Westport and Ameristar Casino Resort and Spa are two additional hotels that offer an onsite pool. View all hotels with pools in Defiance.

What's the best place to stay near Lambert-St. Louis International Airport (STL)?

Marriott St. Louis Airport is a popular 3.5-star hotel featuring a restaurant and an outdoor pool. It's located a short 0.3 mi (0.5 km) from Lambert-St. Louis Intl. Airport. Other good choices within close proximity to the airport include Pear Tree Inn Airport - St. Louis - St. Ann, MO and Drury Inn & Suites St. Louis Airport.

What's it like to stay in Defiance?

Visitors can enjoy all that Defiance has to offer including the wineries and parks. Top sights in the area include St. Louis Union Station, Busch Stadium, and Gateway Arch. In Defiance, there are 20 hotels and other accommodations to choose from. Find out more about Defiance.

What is there to see in Defiance?

Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River, and Matson Hill Park Trailhead. A couple of additional sights to add to your agenda are Yellow Farmhouse Winery and Chandler Hill Vineyards. Check out what more to see and do in Expedia's Defiance guide.

What's the seasonal weather like in Defiance?

The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.