Top 10 Hotels in Defiance, MO from ₩104,699 - Competitive Prices

A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

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Our top choices for Defiance hotels

An outdoor patio area with a stone fire pit, wicker furniture, and a covered seating area with a view of the building's interior.

A hotel room with a sofa, a side table, a lamp, a flat-screen TV, and a bed with a red blanket.

A modern kitchen with wooden cabinets, a stainless steel countertop, and various appliances including a coffee maker and a rice cooker.

A multi-story hotel with a brick facade, a covered outdoor seating area with a fire feature, and a sign indicating it is a Marriott property.

1. TownePlace Suites by Marriott St. Louis Chesterfield

Chesterfield

Bobbi jo

₩171,328

₩201,076 total

includes taxes & fees

Oct 15 - Oct 16

A hotel room with a bed, a sofa, a coffee table, and wall art.

A restaurant with wooden tables and chairs, a blue wall with white floral patterns, and a counter with a coffee machine.

An indoor swimming pool with a clear view of the outside, a metal ladder, and a ceiling with recessed lighting.

A hotel lobby with a reception desk, seating area, and a large potted plant.

2. Sleep Inn & Suites O'Fallon MO - Technology Drive

O'Fallon

Tim

₩105,808

₩124,801 total

includes taxes & fees

Nov 2 - Nov 3

A hotel room with a bed, desk, chair, television, and artwork on the wall.

A hotel room with two beds, a desk with a chair, a television, and a window with curtains.

A hotel lobby with a seating area, a reception desk, and a flat-screen TV mounted on the wall.

A reception desk with a modern design, featuring a blue geometric wall and a wooden finish.

3. Holiday Inn Express St. Louis West - O'Fallon by IHG

O'Fallon

Greg

₩119,127

₩140,510 total

includes taxes & fees

Oct 11 - Oct 12

A multi-story hotel with a central entrance featuring a covered patio area.

A hotel room with a sofa, armchair, bedside table, lamp, TV, and a bed with patterned bedding.

A hotel with a swimming pool, outdoor seating, and a covered patio area.

A hotel lobby with a sectional sofa, a fireplace, a flat-screen TV, and framed artwork on the walls.

4. Staybridge Suites O'Fallon Chesterfield by IHG

O'Fallon

Norman

₩157,943

₩186,295 total

includes taxes & fees

Oct 11 - Oct 12

A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.

A modern bathroom with a large mirror, white vanity, and a bathtub.

A formal dining table set for six with a vase of white flowers, candles, and a view of buildings through large windows.

A hotel room with a large bed, a bedside lamp, a telephone, a mirror, and a bathroom with a sink and towel rack.

5. The Wildwood Hotel

Wildwood

Ryan

₩110,702

₩128,954 total

includes taxes & fees

Nov 2 - Nov 3

A modern dining area with a brick fireplace, yellow and blue chairs, and a blue sofa.

A hotel with a brick facade, multiple parking spaces, and a grassy area in the foreground.

A gym with a treadmill, elliptical, stationary bike, and a rack of dumbbells.

A hotel room with two beds, a desk, a mirror, and a wardrobe.

6. Comfort Inn & Suites Chesterfield - St. Louis

Chesterfield

Brenda

₩112,635

₩135,750 total

includes taxes & fees

Oct 13 - Oct 14

A spacious lobby with a stone fireplace, seating area, and a bar with high stools.

A modern living room with a fireplace, a flat-screen TV, a sofa, a coffee table, and a dining area.

A hotel lobby with a seating area featuring two armchairs, a round coffee table, and a flat-screen TV mounted on a wooden wall.

A hotel pantry stocked with beverages and snacks, a refrigerated display case, and a sign reading "The Market".

7. Residence Inn by Marriott O'Fallon

O'Fallon

Rianna

₩175,344

₩206,818 total

includes taxes & fees

Oct 30 - Oct 31

A spacious lobby with a high ceiling, a central seating area with sofas and a coffee table, and a large window providing natural light.

A spacious lobby with a sofa, a coffee station, and a reception desk.

A hotel with a covered entrance, multiple flags, and a well-maintained lawn.

A spacious lobby with a fireplace, comfortable seating, a large painting, and a view of the kitchen area.

8. Hilton Garden Inn St. Louis/O'Fallon MO

O'Fallon

Kassie

₩144,879

₩171,791 total

includes taxes & fees

Oct 18 - Oct 19

An outdoor patio area with wicker furniture and a central fire feature.

A hotel room with a bed, a sofa, a desk, and a chair.

A modern hotel lobby with a bar area, seating arrangements, and a reception desk.

A Courtyard Marriott hotel with a parking lot and a green shuttle service.

9. Courtyard by Marriott St. Louis Chesterfield

Chesterfield

Kelly

₩160,940

₩187,275 total

includes taxes & fees

Oct 19 - Oct 20

Two people in a swimming pool with colorful inflatable rings.

A buffet counter with a variety of food items, including pastries and beverages, and a person serving.

A lobby with a grand staircase, two patterned sofas, a glass coffee table, and a large mirror.

A hotel room with a large bed, a desk, a TV, and a view of a pool through the glass door.

10. Holiday Inn St. Louis West Six Flags by IHG

Eureka

Rob

₩157,943

₩184,004 total

includes taxes & fees

Oct 18 - Oct 19

A spacious lobby with a high ceiling, a dining area, and a kitchen in the background.

A hotel room with a bathroom, a bed, a nightstand, and a window.

An indoor swimming pool with stone flooring, white walls, and a green stripe. There are chairs and a door with a sign.

A modern hotel lobby with a computer desk, a flat-screen TV, and a ceiling fan.

11. Quality Inn Near Six Flags St. Louis

Pacific

Rachel

₩130,276

₩149,135 total

includes taxes & fees

Oct 26 - Oct 27

A courtyard with a central seating area, surrounded by trees and a building with a pitched roof.

A modern hotel room with a large window, a desk with a flat-screen TV, a comfortable seating area, and a decorative wall piece.

A modern dining area with a long table, multiple chairs, and pendant lighting.

A store interior with a 'Treats' sign, snack shelves, and a chalkboard with a welcome message.

12. Hampton Inn & Suites St. Louis/Chesterfield

Chesterfield

Vijay

₩152,562

₩177,527 total

includes taxes & fees

Nov 1 - Nov 2

A modern kitchen area with a breakfast bar, a coffee machine, and a refrigerator displaying menu options.

A hotel room with two beds, a blue sofa, a small table, and a kitchenette.

A pool area with a blue pool lift chair, a pool user capacity sign, and a tiled wall.

A coffee station with two coffee machines and a display of coffee pods and cups.

13. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Chesterfield

Terry

₩152,589

₩177,558 total

includes taxes & fees

Oct 11 - Oct 12

A modern kitchen with a bar area, wooden cabinets, and pendant lighting.

A modern hotel entrance with a glass canopy, large windows, and a brick facade.

A hotel room with two beds, a sofa, a small table, a lamp, and a framed abstract painting on the wall.

A swimming pool with a tiled deck, a sunlit room with a view, and a seating area with chairs.

14. Hyatt Place St. Louis/Chesterfield

Chesterfield

Debbie

₩161,423

₩187,232 total

includes taxes & fees

Oct 18 - Oct 19

A spacious lobby with a central round table, two sofas, and a chandelier.

A hotel room with two beds, a patterned wall, and a view of the city through sheer curtains.

A Drury Plaza hotel with a modern design, featuring a curved facade, large windows, and a Drury Plaza sign on the top.

A buffet setup with various food items and a decorative vase of flowers.

15. Drury Plaza Hotel St. Louis Chesterfield

Chesterfield

Parvaneh Pattie

₩173,992

₩201,808 total

includes taxes & fees

Oct 13 - Oct 14

An indoor swimming pool with a hot tub, clear signage, and a view of the outside through large windows.

A modern hotel room with a grey sofa, a wooden coffee table, a flat-screen TV, a wooden dresser, and a large window with curtains.

A spacious living area with a blue wall, yellow armchairs, a blue sofa, and a wooden coffee table.

A modern dining area with yellow and blue chairs, a flat-screen TV, and a kitchen area with appliances.

16. Comfort Inn Near Six Flags St. Louis

Pacific

Gail

₩133,796

₩153,163 total

includes taxes & fees

Oct 28 - Oct 29

An outdoor patio with a built-in grill, seating area, and stone walls.

A multi-story hotel with a parking lot in front.

A modern lobby with a stone accent wall, a flat-screen TV, a reception desk, seating area with sofas and ottomans, and a patterned rug.

An indoor swimming pool with clear glass walls, sunlit seating area, and lifeguard station.

17. Residence Inn by Marriott St. Louis Chesterfield

Chesterfield

Chelsea

₩252,977

₩295,953 total

includes taxes & fees

Oct 15 - Oct 16

A spacious living room with a large painting, a fireplace, a staircase, and modern furniture.

An outdoor patio with a beige sofa set, two armchairs, and a table.

A hotel room with a dining area, a fireplace, and a view of the outdoors.

A swimming pool with tiled edges and a hot tub area, surrounded by windows and chairs.

18. Best Western Plus Washington Hotel

Washington

Shawn

₩172,667

₩196,580 total

includes taxes & fees

Oct 11 - Oct 12

A spacious hotel lobby with a long reception desk, multiple seating areas, and large windows allowing natural light.

An indoor swimming pool with a clear water area, a shallow end, and a tiled deck surrounding the pool. There are lounge chairs and tables on the deck, and a sign indicating a maximum capacity of 62.

A modern hotel room with a neatly made bed, a bedside table with a lamp, a wall-mounted artwork, and a small seating area with a bench.

A Hampton Inn with a brick facade, outdoor seating area, and a clear sky.

19. Hampton Inn St. Louis Wentzville

Wentzville

Jill

₩185,489

₩210,437 total

includes taxes & fees

Nov 1 - Nov 2

A Super 8 hotel with a flat facade, multiple windows, and a parking lot.

A breakfast area with wooden cabinets, a coffee station, and a dining table with chairs.

A hotel room with a bed, a desk, a chair, a nightstand, a lamp, and a large cityscape artwork on the wall.

A hotel room with a flat-screen TV, a wooden dresser, a beige sofa, a teal carpet, and a window with curtains.

20. Super 8 by Wyndham Eureka/Six Flags Nearby

Eureka

Claire

₩89,880

₩104,699 total

includes taxes & fees

Oct 20 - Oct 21

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Stay near popular Defiance attractions

A glass of red wine on a wooden table with a vineyard in the background.

Chandler Hill Vineyards

7.8/10 (7 reviews)

This elegant Missouri winery showcases local and California wines from its hillside setting. Savor varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen.

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A wooden dock extending into a pond with lily pads, surrounded by lush greenery and a clear blue sky.

August A. Busch Memorial Conservation Area

8.6/10 (7 reviews)

This sprawling conservation area features over 30 lakes and historic WWII bunkers amid diverse habitats. Explore well-maintained trails while watching for migratory birds and wildlife in their natural environment.

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Sugar Creek Winery

8.0/10 (1 review)

Sip award-winning Missouri wines at this hillside vineyard along the scenic Katy Trail. Relax on covered decks with your own picnic while enjoying live weekend music and panoramic countryside views.

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Historic Daniel Boone Home and Heritage Center

9.6/10 (4 reviews)

Step into the limestone home where Daniel Boone's son Nathan crafted a frontier masterpiece with seven fireplaces. Explore the surrounding historic village for an authentic glimpse into 19th-century pioneer life.

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Broemmelsiek Park

This 494-acre natural playground offers nine miles of trails through forests and around serene lakes. Attend a monthly stargazing event at the astronomy viewing area for a uniquely celestial park experience.

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Yellow Farmhouse Winery

This boutique winery in Defiance, Missouri was known for its distinctive unfiltered wines and relaxed atmosphere. Visitors could enjoy tastings with live music while picnicking on scenic grounds with vineyard views.

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Matson Hill Park Trailhead

Wander through 475 acres of rugged forest terrain with challenging hiking paths and gravity-flow mountain bike trails. The historic 1830s Hays Home offers a glimpse into pioneer life amid the natural splendor.

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Hamburg Trail Trailhead

This moderate 6.9-mile loop winds through the scenic Weldon Spring Conservation Area, connecting to the Katy Trail State Park. Spot native wildlife while traversing diverse landscapes of shaded woodlands and open fields.

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Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance

Top Defiance Hotel Reviews

Sleep Inn & Suites O'Fallon MO - Technology Drive

10/10 Excellent

"It was close to everything"

Hyatt Place St. Louis/Chesterfield

10/10 Excellent

"Very clean hotel."

Drury Inn & Suites St. Louis St. Peters

10/10 Excellent

"Great hotel"

Hampton Inn St. Charles St. Peters

10/10 Excellent

"Everything looks new and good smell 10/10 overall"

Wingate by Wyndham St. Louis/Fenton Route 66

10/10 Excellent

"Good channel sel"

Studio 6 Extended Stay - St Louis, MO - Westport/Craig Road

8/10 Good

"Hotel is in a safe, convenient location. NO elevator, but there was an entrance with no steps on the first level. The hallway is a little grody but the room was very clean and arranged in a very convenient way. Lots of space to set things out to organize. Full kitchen but no utensils or cooking pans or dishes. I suppose they would be stolen if they were provided. I did not need them anyway. No ice machine, but ice trays to make your own ice in the freezer. Nice TV with lots of channels. Comfortable bed but lumpy pillow. Nice shower and bathroom. Basically it was perfect for my purposes as I was attending a meeting just down the street at a more expensive hotel. Families do live there and there was more noise in the hall than some would probably like. I ignored it. The office does not open until 9 in the morning and I had to be at my meeting before that time on the day of checkout. So, I had to return in the afternoon as I wanted my checkout paper. The staff was very nice and very helpful."

More cheap stays in Defiance

Sleep Inn & Suites O'Fallon MO - Technology Drive

1147 Technology Drive O'Fallon MO

₩105,808

₩124,801 total

Nov 2 - Nov 3

includes taxes & fees

9/10 Wonderful! (1,133 reviews)

Country Inn & Suites by Radisson, St. Peters, MO

3877 Veterans Memorial Pkwy St. Charles MO

₩114,469

₩131,581 total

Nov 1 - Nov 2

includes taxes & fees

Quality Inn Foristell

12 Highway W Foristell MO

₩118,056

₩133,345 total

Oct 26 - Oct 27

includes taxes & fees

8.2/10 Very Good! (1,000 reviews)

Comfort Suites St Charles - St Louis

1400 S 5th St St. Charles MO

₩129,079

₩148,347 total

Oct 18 - Oct 19

includes taxes & fees

8.4/10 Very Good! (1,007 reviews)

Hampton Inn St. Charles St. Peters

3720 W Clay St St. Charles MO

₩158,853

₩182,558 total

Oct 29 - Oct 30

includes taxes & fees

8.2/10 Very Good! (1,000 reviews)

Country Inn & Suites by Radisson, St. Charles Historic District

1190 S Main St St. Charles MO

₩179,024

₩205,746 total

Nov 1 - Nov 2

includes taxes & fees

Frequently asked questions

What's the best place to stay in Defiance?

Hollywood Casino & Hotel St. Louis, located 18.1 mi (29.2 km) from the heart of Defiance, is a top choice for your stay based on our traveler data. Other good choices for your stay in the area are Sonesta ES Suites St. Louis - Chesterfield and Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham. See all available top hotels, or vacation rentals in Defiance.

If I need to cancel my hotel reservation in Defiance, will I receive a refund?

Yes, the majority of hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a reservation that's non-refundable, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.

Where can I learn more about changing or cancelling my trip to Defiance?

For more information about changing or cancelling your trip to Defiance, head over to our customer service page.

Where is the best hotel to stay with easy access to August A. Busch Memorial Conservation Area?

Sleep Inn & Suites O'Fallon MO - Technology Drive is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located 2.6 mi (4.3 km) from August A. Busch Memorial Conservation Area. Other good options within a few miles include Hilton Garden Inn St. Louis/O'Fallon MO and Holiday Inn Express St. Louis West - O'Fallon, an IHG Hotel.

What about the best place to stay near Chandler Hill Vineyards?

One of the top choices for your stay is The Wildwood Hotel, located 10 mi (16.1 km) from Chandler Hill Vineyards, and this 3.5-star hotel offers free breakfast and an indoor pool.

What are some accommodations with pools in Defiance?

Sonesta ES Suites St. Louis - Chesterfield: Offers daily, a seasonal outdoor pool, and free self parking. Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham and Ameristar Casino Resort and Spa are two additional hotels that offer an onsite pool. View all hotels with pools in Defiance.

What's the best place to stay near Lambert-St. Louis International Airport (STL)?

Marriott St. Louis Airport is a popular 3.5-star hotel featuring a restaurant and an outdoor pool. It's located a short 0.3 mi (0.5 km) from Lambert-St. Louis Intl. Airport. Other good choices within close proximity to the airport include Pear Tree Inn Airport - St. Louis - St. Ann, MO and Drury Inn & Suites St. Louis Airport.

What's it like to stay in Defiance?

Visitors can enjoy all that Defiance has to offer including the wineries and parks. Top sights in the area include St. Louis Union Station and St. Louis Zoo. In Defiance, there are 19 hotels and other accommodations to choose from. Find out more about Defiance.

What is there to see in Defiance?

Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River, and Matson Hill Park Trailhead. A couple of additional sights to add to your agenda are Yellow Farmhouse Winery and Chandler Hill Vineyards. Check out what more to see and do in Expedia's Defiance guide.

What's the seasonal weather like in Defiance?

The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.

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Find hotels in Defiance, MO from ₩104,699

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Defiance

Check prices for these dates

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Star rating

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Our top choices for Defiance hotels

1. TownePlace Suites by Marriott St. Louis Chesterfield

2. Sleep Inn & Suites O'Fallon MO - Technology Drive

3. Holiday Inn Express St. Louis West - O'Fallon by IHG

4. Staybridge Suites O'Fallon Chesterfield by IHG

5. The Wildwood Hotel

6. Comfort Inn & Suites Chesterfield - St. Louis

7. Residence Inn by Marriott O'Fallon

8. Hilton Garden Inn St. Louis/O'Fallon MO

9. Courtyard by Marriott St. Louis Chesterfield

10. Holiday Inn St. Louis West Six Flags by IHG

11. Quality Inn Near Six Flags St. Louis

12. Hampton Inn & Suites St. Louis/Chesterfield

13. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

14. Hyatt Place St. Louis/Chesterfield

15. Drury Plaza Hotel St. Louis Chesterfield

16. Comfort Inn Near Six Flags St. Louis

17. Residence Inn by Marriott St. Louis Chesterfield

18. Best Western Plus Washington Hotel

19. Hampton Inn St. Louis Wentzville

20. Super 8 by Wyndham Eureka/Six Flags Nearby

Stay near popular Defiance attractions

Chandler Hill Vineyards

August A. Busch Memorial Conservation Area

Sugar Creek Winery

Historic Daniel Boone Home and Heritage Center

Broemmelsiek Park

Yellow Farmhouse Winery

Matson Hill Park Trailhead

Hamburg Trail Trailhead

Learn more about Defiance

Top Defiance Hotel Reviews

Sleep Inn & Suites O'Fallon MO - Technology Drive

Hyatt Place St. Louis/Chesterfield

Drury Inn & Suites St. Louis St. Peters

Hampton Inn St. Charles St. Peters

Wingate by Wyndham St. Louis/Fenton Route 66

Studio 6 Extended Stay - St Louis, MO - Westport/Craig Road

More cheap stays in Defiance

Sleep Inn & Suites O'Fallon MO - Technology Drive

Country Inn & Suites by Radisson, St. Peters, MO

Quality Inn Foristell

Comfort Suites St Charles - St Louis

Hampton Inn St. Charles St. Peters

Country Inn & Suites by Radisson, St. Charles Historic District

Frequently asked questions

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