Find hotels in Otay Mesa, San Diego

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Otay Mesa hotels

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.2 out of 10, Very Good, (1,731 reviews)
"great breakfast and nice staff"
United States
rosita
The price is ₩182,536
₩207,642 total
includes taxes & fees
May 17 - May 18
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.0 out of 10, Good, (1,008 reviews)
"Good for short stay"
Japan
Yuki
The price is ₩150,288
₩170,953 total
includes taxes & fees
May 25 - May 26
Quality Suites San Diego Otay Mesa

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,900 reviews)
"Great stay"
United States
Zuhair
The price is ₩155,156
₩188,056 total
includes taxes & fees
May 26 - May 27
Sycuan Casino Resort

Days Inn by Wyndham San Diego-East/El Cajon

Days Inn by Wyndham San Diego-East/El Cajon
2.0 star property
27.3 km from Otay Mesa
7.8 out of 10, Good, (1,008 reviews)
"Clean rooms Good breakfast Excellent staff"
United States
Dulce j
The price is ₩128,065
₩141,118 total
includes taxes & fees
May 10 - May 11
Days Inn by Wyndham San Diego-East/El Cajon

Courtyard by Marriott San Diego El Cajon

Courtyard by Marriott San Diego El Cajon
3.0 star property
26.3 km from Otay Mesa
9.2 out of 10, Wonderful, (1,005 reviews)
"Really nice staff and great hotel!"
Canada
Shana
The price is ₩226,475
₩249,564 total
includes taxes & fees
May 25 - May 26
Courtyard by Marriott San Diego El Cajon

Best Western Plus La Mesa San Diego

Best Western Plus La Mesa San Diego
2.5 star property
24.6 km from Otay Mesa
8.4 out of 10, Very Good, (1,017 reviews)
"Clean room, clean property, kind staff, great breakfast, very spacious rooms."
United States
Sergio
The price is ₩199,500
₩219,450 total
includes taxes & fees
May 26 - May 27
Best Western Plus La Mesa San Diego

SpringHill Suites by Marriott Chula Vista Eastlake

SpringHill Suites by Marriott Chula Vista Eastlake
3.5 star property
10.5 km from Otay Mesa
9.6 out of 10, Exceptional, (643 reviews)
"Best hotel ever!"
United States
Nicholas
The price is ₩335,142
₩369,310 total
includes taxes & fees
May 18 - May 19
SpringHill Suites by Marriott Chula Vista Eastlake

Heritage Inn La Mesa

Heritage Inn La Mesa
2.0 star property
24.3 km from Otay Mesa
7.0 out of 10, Good, (1,437 reviews)
"Good and quick good customer service"
United States
Angel
The price is ₩104,046
₩114,650 total
includes taxes & fees
May 10 - May 11
Heritage Inn La Mesa

Lamplighter Inn & Suites at SDSU

Lamplighter Inn & Suites at SDSU
2.5 star property
24.4 km from Otay Mesa
9.0 out of 10, Wonderful, (1,415 reviews)
"Clean room, beautiful landscaping, adequate breakfast, easy parking. "
United States
Deborah
The price is ₩224,331
₩252,928 total
includes taxes & fees
May 18 - May 19
Lamplighter Inn & Suites at SDSU

La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
12.9 km from Otay Mesa
8.6 out of 10, Excellent, (1,618 reviews)
"Great stay"
United States
Helda
The price is ₩146,536
₩161,190 total
includes taxes & fees
May 25 - May 26
La Quinta Inn by Wyndham San Diego Chula Vista

Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
2.5 star property
13 km from Otay Mesa
8.2 out of 10, Very Good, (1,475 reviews)
"We really enjoyed our stay here! Breakfast in the morning was great & staff was always friendly & helpful!"
United States
Megan
The price is ₩147,405
₩162,440 total
includes taxes & fees
May 25 - May 26
Comfort Inn Chula Vista San Diego South

Studio 6 Suites San Ysidro, CA -San Diego South Bay

Studio 6 Suites San Ysidro, CA -San Diego South Bay
2.5 star property
6.9 km from Otay Mesa
8.0 out of 10, Very Good, (1,640 reviews)
"Clean room, friendly and nice staff, easy parking and safe "
United States
Erik
The price is ₩106,580
₩121,438 total
includes taxes & fees
May 10 - May 11
Studio 6 Suites San Ysidro, CA -San Diego South Bay

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
8 km from Otay Mesa
9.0 out of 10, Wonderful, (1,271 reviews)
"Clean room, nice staff, a simple breakfast, and free parking on site."
United States
Nicole
The price is ₩177,205
₩201,570 total
includes taxes & fees
May 13 - May 14
Best Western Americana Inn

Hotel Palmeras Chula Vista

Hotel Palmeras Chula Vista
2.0 star property
14.4 km from Otay Mesa
7.2 out of 10, Good, (2,230 reviews)
"The parking was not bad at all the AC and all the amenities were really good to have during our trip"
United States
Jesus
The price is ₩110,159
₩121,175 total
includes taxes & fees
May 12 - May 13
Hotel Palmeras Chula Vista

Springhill Suites San Diego Mission Valley

Springhill Suites San Diego Mission Valley
3.5 star property
28.2 km from Otay Mesa
9.2 out of 10, Wonderful, (1,005 reviews)
"additional, the location is perfect for most of resorts, "
United States
xiaoyang
The price is ₩215,856
₩248,116 total
includes taxes & fees
May 10 - May 11
Springhill Suites San Diego Mission Valley

Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
14.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,134 reviews)
"The room was lovely and clean friendly staff, nice breakfast"
United Kingdom
Niki Andrew
The price is ₩172,395
₩189,635 total
includes taxes & fees
May 25 - May 26
Holiday Inn Express San Diego South - Chula Vista by IHG

San Diego Marriott Mission Valley

San Diego Marriott Mission Valley
4.0 star property
28.6 km from Otay Mesa
8.8 out of 10, Excellent, (1,006 reviews)
"Good to stay "
United States
Tamaz
The price is ₩259,317
₩298,072 total
includes taxes & fees
May 17 - May 18
San Diego Marriott Mission Valley

Hercor Hotel - Urban Boutique

Hercor Hotel - Urban Boutique
3.0 star property
13.6 km from Otay Mesa
8.6 out of 10, Excellent, (1,441 reviews)
"Clean room, friendly staff "
United States
Avery
The price is ₩137,089
₩151,065 total
includes taxes & fees
May 10 - May 11
Hercor Hotel - Urban Boutique

Berkshire Motor Hotel

Berkshire Motor Hotel
2.5 star property
North Park, 26.7 km from Otay Mesa
8.4 out of 10, Very Good, (1,000 reviews)
"Very comfortable room and close to cool restaurants"
United States
Samantha
The price is ₩130,253
₩146,855 total
includes taxes & fees
May 10 - May 11
Berkshire Motor Hotel

The Rambler Hotel

The Rambler Hotel
3.0 star property
14.8 km from Otay Mesa
9.0 out of 10, Wonderful, (2,134 reviews)
"Such an adorable property in a great location!"
United States
Kory
The price is ₩157,908
₩182,695 total
includes taxes & fees
May 10 - May 11
The Rambler Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most.

Downtown San Diego

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

Pacific Beach

Boasting a lively nightlife scene, Pacific Beach offers miles of sandy shores, a bustling 3.2-mile boardwalk, and attractions like Crystal Pier and Kate Sessions Park. Enjoy local shops, bars, and eateries along the vibrant walkway.

Mission Beach

Spanning nearly two miles of oceanfront, this sandbar community offers sunbathing, surfing, and beach volleyball, with nearby attractions like Belmont Park's Giant Dipper Roller Coaster and SeaWorld in Mission Bay Park.

Gaslamp Quarter

Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.

Ocean Beach

Ocean Beach is known for its stunning beaches, and with sights like Dog Beach and Ocean Beach, you won't get bored spending a day wandering around this part of San Diego.

Top Otay Mesa Hotel Reviews

Frequently asked questions

What's it like in Otay Mesa?
Otay Mesa is a neighborhood that travelers like for its beaches, restaurants, and shopping.
Where is the best hotel for a stay in Otay Mesa?
Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa.
If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?
Yes! The majority of hotel reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within a 24-hour period of booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Otay Mesa.
Where can I learn more about changing or cancelling my trip to Otay Mesa?
To find more details about changing or cancelling your trip to Otay Mesa, go to https://www.expedia.com/service/.
What is there to do in this San Diego neighborhood?
A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana, and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.