The Best Hotels Closest to James S. McDonnell Prologue Room in St. Louis for 2026

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Our top choices for James S. McDonnell Prologue Room hotels

A spacious lobby with modern seating, a reception desk, and large windows offering views of the parking area.

A spacious indoor area with a high ceiling and large windows, featuring multiple seating areas with sofas and chairs, and a visible outdoor view through the windows.

A seating area with three grey armchairs and a central glass-top table, a wooden floor, and a view of parked cars through large windows.

A spacious indoor area with multiple wooden tables and chairs, large windows, and a high ceiling with exposed beams.

1. Pear Tree Inn St. Louis Airport

2.6 km from James S. McDonnell Prologue Room

Darren

₩123,070

₩144,900 total

includes taxes & fees

Sep 10 - Sep 11

A modern hotel room with a dining area, wooden cabinets, a checkered floor, and a flat-screen TV.

A hotel room with two beds, a desk, a chair, and a large window with curtains.

A lobby with two orange armchairs, a small table, a flat-screen TV, framed pictures, and a wall-mounted shelf with decorative items.

A Wingate hotel with a covered entrance, outdoor seating, and a parking lot.

2. Wingate by Wyndham St. Louis Airport

2.5 km from James S. McDonnell Prologue Room

Margaret

₩151,120

₩177,925 total

includes taxes & fees

Sep 13 - Sep 14

A modern living room with a built-in fireplace, a large flat-screen TV, a unique hexagonal pendant light, and a patterned rug.

A modern lobby with blue seating, a reception desk, and large windows.

A modern dining area with a long table, multiple chairs, and a unique chandelier.

A multi-story hotel with a stone facade, a covered entrance, and a parking lot.

3. Hyatt Select St. Louis Airport

1.9 km from James S. McDonnell Prologue Room

Paige

₩150,436

₩184,996 total

includes taxes & fees

Sep 20 - Sep 21

A multi-level hotel lobby with seating areas, a reception desk, and large windows offering views.

A hotel room with a bed, two armchairs, a sofa, a small table, and a nightstand.

A pool area with two hot tubs, seating, and a view of the outdoors.

A modern kitchen with a stainless steel range hood, a bar area with stools, and a large window providing a view of the outdoors.

4. Drury Inn & Suites St. Louis Airport

2.1 km from James S. McDonnell Prologue Room

Hema

₩157,260

₩184,525 total

includes taxes & fees

Sep 20 - Sep 21

A hotel lobby with a reception desk, seating area, and a view of the parking lot.

An indoor swimming pool with clear glass walls, blue lounge chairs, and a lifeguard stand.

A snack vending machine with various snack options.

A modern hotel with a prominent Hilton sign, a Hampton Inn by Hilton sign, and a parking lot with a covered area and landscaped beds.

5. Hampton Inn By Hilton St Louis Airport

2 km from James S. McDonnell Prologue Room

Carrie

₩187,378

₩223,616 total

includes taxes & fees

Sep 7 - Sep 8

A Holiday Inn Express & Suites building with a covered entrance, stone pillars, and a landscaped area in front.

An indoor swimming pool with clear water, surrounded by tiled walls and a brick floor.

A hotel lobby with a reception desk, seating area, and a large decorative wall.

A breakfast buffet with labeled sections for fruit and cereal.

6. Holiday Inn Express & Suites St Louis Airport by IHG

2 km from James S. McDonnell Prologue Room

Keneace

₩162,221

₩199,119 total

includes taxes & fees

Sep 13 - Sep 14

A buffet with fruits, pastries, and beverages.

The Renaissance Hotel with a modern architectural design, featuring a prominent central entrance and a symmetrical facade.

A modern living room with a flat-screen TV, comfortable seating, and decorative items on shelves.

A spacious hotel lobby with multiple seating areas, a reception desk, and large windows offering a view of the cityscape.

7. Renaissance St. Louis Airport Hotel

Berkeley, 2 km from James S. McDonnell Prologue Room

Arnetta

₩175,053

₩204,791 total

includes taxes & fees

Sep 13 - Sep 14

A modern dining area with round tables, orange chairs, and a decorative wall with pottery.

A Marriott hotel with a large building, multiple flags, and a well-lit entrance area.

A modern hotel lobby with a bar area, seating arrangements, and decorative lighting.

A swimming pool with a glass enclosure, a lounge area with orange chairs, and a view of a landscaped garden.

8. Marriott St. Louis Airport

2.4 km from James S. McDonnell Prologue Room

Chris

₩195,020

₩232,733 total

includes taxes & fees

Sep 18 - Sep 19

A modern interior with a wooden panel wall, a kitchen area, and a dining space with pendant lighting.

A hotel room with a bed, a desk, a chair, a small table, a framed artwork, and a bathroom with a mirror and sink.

A hotel room with a large bed, a chair, a table, and a cityscape mural on the wall.

A modern hotel with a prominent DoubleTree by Hilton sign, a well-lit entrance, and a landscaped front yard.

9. DoubleTree by Hilton St. Louis Airport

2.1 km from James S. McDonnell Prologue Room

Emanuel

₩156,694

₩183,862 total

includes taxes & fees

Oct 2 - Oct 3

A bar area with a long counter, multiple seating options, and a television screen displaying a program.

A multi-story hotel with a central courtyard, surrounded by trees and a parking lot.

A hotel lobby with a central seating area featuring sofas and tables, a large TV screen displaying a sports game, and a bar area with chairs and a counter.

A modern hotel lobby with a sectional sofa, round tables, and a bar area.

10. Hilton St. Louis Airport

1.9 km from James S. McDonnell Prologue Room

Tony

₩195,020

₩232,752 total

includes taxes & fees

Sep 13 - Sep 14

A hotel dining area with multiple tables and chairs, a sofa, and a large window with curtains.

A hotel room with a round wooden dining table, a sofa, two lamps, and framed pictures on the walls.

A hotel with a beige facade, a clear sign reading "Quality Inn," and a parking lot with a red car.

A workspace with two desks, two computers, a clock, and a framed picture on the wall.

11. Quality Inn Florissant - St Louis

3.1 km from James S. McDonnell Prologue Room

vaughnzell

₩91,834

₩108,456 total

includes taxes & fees

Sep 27 - Sep 28

A reception desk with a cityscape on the monitor, a blue-lit ceiling, and a sign for key drop-off.

A restaurant with tables and chairs, a coffee machine, and a refrigerator.

Two white front-loading washers stacked on top of each other with a Gain detergent box and a Whirlpool instruction manual on the top washer.

A hotel room with a large bed, two bedside tables, a TV, a desk, and a window with curtains.

12. Travelodge by Wyndham St. Louis

Berkeley, 2.4 km from James S. McDonnell Prologue Room

LIXIN

₩87,526

₩103,554 total

includes taxes & fees

Sep 20 - Sep 21

A hotel entrance with a covered waiting area, a parking lot, and a building with multiple windows and a green exterior.

A parking lot with several cars, a U-Haul truck, and a building with a green sign for HomeTowne Studios.

A hotel room with two beds, a desk, a chair, a wardrobe, and a bathroom door.

A reception area with a green wall, a reception desk, a framed picture, and a wooden floor.

13. HomeTowne Studios by Red Roof St. Louis - Airport/ N Lindbergh

2.9 km from James S. McDonnell Prologue Room

Kimberly

₩102,556

₩125,362 total

includes taxes & fees

Sep 3 - Sep 4

A compact kitchen with dark cabinets, a white countertop, a stove, and a refrigerator.

A reception area with two leather chairs, a small table, a potted plant, and a framed picture on the wall.

A brick building with a central entrance, numbered 155, and a sign indicating 'Lobby'.

14. Welcome Suites Hazelwood

3 km from James S. McDonnell Prologue Room

"I booked a handicapped accessible room. Upon arriving the desk clerk saw my wheelchair and asked how I planned to get upstairs because they had no elevator or open rooms on the 1st floor. I told him I already paid for a night to secure the room and he assured me I wouldn't be charged. I was not only charged but they lied to my bank and my bank refused my dispute for the charges. I wish I had read the reviews first, they seem to screw people over regularly. People don't stay in run down...

Leanna

₩76,927

₩94,034 total

includes taxes & fees

Sep 3 - Sep 4

A hotel room with a bed, bedside table, lamp, TV, and a desk with a chair.

A spacious dining area with multiple tables and chairs, a kitchen area with dark cabinets, and a flat-screen TV mounted on the wall.

A spacious lobby with a patterned tile floor, a staircase, and seating areas.

A reception area with a marble floor, a reception desk, and a sign that says "Quality."

15. Quality Inn Saint Louis Airport

2 km from James S. McDonnell Prologue Room

Gordon

₩79,950

₩98,392 total

includes taxes & fees

Sep 20 - Sep 21

A modern lobby with orange seating, a flat-screen TV, and a stone accent wall.

A spacious lobby with a large sectional sofa, a reception desk, and a bar area.

A hotel pool area with a hot tub, lounge chairs, and a 'No Diving Allowed' sign.

A gym with treadmills, stationary bikes, and a weight machine.

16. Drury Plaza Hotel St. Louis St. Charles

12.8 km from James S. McDonnell Prologue Room

Robert

₩196,576

₩227,884 total

includes taxes & fees

Sep 7 - Sep 8

A courtyard with outdoor seating, a central fountain, and a view of a tower.

A buffet setup with various food items, a coffee station, and a refrigerator with beverages.

The exterior of the Charles F. Knight Center with a stone facade, large arched entrance, and a sign above the doors.

A spacious lobby with a bar area, seating arrangements, and a clock on the wall.

17. The Knight Center at Washington University

11.4 km from James S. McDonnell Prologue Room

Nija

₩156,152

₩179,557 total

includes taxes & fees

Sep 20 - Sep 21

A restaurant with round tables and chairs, a bar area, and a patterned ceiling.

A hotel room with a large bed, a desk with a chair, a television, and a wardrobe.

An indoor swimming pool with clear glass walls, a tiled floor, and a 'Step Down' sign.

A spa bath with a sign indicating a capacity of 8 persons.

18. Drury Plaza Hotel St. Louis Brentwood

13.6 km from James S. McDonnell Prologue Room

Eric

₩185,980

₩220,803 total

includes taxes & fees

Sep 13 - Sep 14

An indoor swimming pool with lounge chairs and a pool table, surrounded by large windows.

A snack and treat display with various products, including chips and beverages, in a store setting.

A hotel with a modern design, featuring a large entrance, multiple floors, and a parking lot.

A spacious room with a long table and chairs, a television mounted on the wall, and a 'Welcome to the Show Nest' sign.

19. Hampton Inn & Suites St. Louis at Forest Park

Dogtown, 14.4 km from James S. McDonnell Prologue Room

Greg

₩190,513

₩224,670 total

includes taxes & fees

Sep 9 - Sep 10

The Clayton Plaza Hotel sign with a stone wall and plants in front.

A hotel room with two beds, a desk, a chair, and a television.

The Clayton Plaza Hotel entrance with a covered walkway and American flags.

20. Clayton Plaza Hotel & Extended Stay

11.2 km from James S. McDonnell Prologue Room

Gail

₩108,928

₩127,161 total

includes taxes & fees

Sep 20 - Sep 21

View all properties

Compare popular hotels close to James S. McDonnell Prologue Room

Property	Property class	Guest rating
Pear Tree Inn St. Louis Airport	9.2 Wonderful 3,204 reviews	View
Wingate by Wyndham St. Louis Airport	9.2 Wonderful 1,724 reviews	View
Hyatt Select St. Louis Airport	9.2 Wonderful 1,003 reviews	View
Drury Inn & Suites St. Louis Airport	9.2 Wonderful 1,396 reviews	View
Hampton Inn By Hilton St Louis Airport	9.0 Wonderful 207 reviews	View

Top James S. McDonnell Prologue Room Hotel Reviews

Holiday Inn Express & Suites St Louis Airport by IHG

10/10 Excellent

"Went down for a weekend getaway and this was nice stay. The hotel, including my king room was extremely clean. Breakfast is pretty good and I like how it's a different selection each day. Close to everything as also. Shout out to all the staff including Vin and Sai for their above and beyond friendliness... I would definitely start again!!!"

Pear Tree Inn St. Louis Airport

10/10 Excellent

"Despite being at the airport and a lot of people a the lobby - it was nice and quite in the room. Comfortable beds, strong A/C, nice shower, big TV. We had a restful night before bouncing to our next destination. Breakfast was excellent in variety with hot and cold items."

La Quinta Inn & Suites by Wyndham St. Louis Hazelwood/ North

10/10 Excellent

"They had a nice selection for breakfast, the room was clean and cool, very friendly guests"

Travelodge by Wyndham St. Louis

10/10 Excellent

"Beds comfortable. Great temperature in rooms. Very spacious rooms. Breakfast ok- just bagels, toast, and cereal offered. Great price though for what is offered. Just needs some updates. It’s not “beautiful” but it is functional and comfortable and quiet."

Drury Inn & Suites St. Louis Airport

10/10 Excellent

"The staff was amazing and helpful. My son left his glasses in our room on our way to Chicago. On our way back they had them ready for us to pick up. Thank you so much guys for being helpful and honest."

Renaissance St. Louis Airport Hotel

10/10 Excellent

"I recommend this Hotel 10 out of 10 every time I go back home this is where I stay. The staff and the facility. Everything is amazing."

Quality Inn Florissant - St Louis

10/10 Excellent

"It's only input that I have is that it's a HomeTown area in that I've been going there for years. It's always been helpful I appreciate the breakfast the gym and the pool. They've all been maintained well over the years I've been coming here. My only complaint would be that there aren't microwaves inside of the rooms anymore for some reason"

Hyatt Select St. Louis Airport

10/10 Excellent

"I forgot some things and they held on to them till I could get them picked up!"

Hampton Inn By Hilton St Louis Airport

10/10 Excellent

"Pleasant stay. Restaurant was good."

Other attractions near James S. McDonnell Prologue Room

Blacks in Flight Mural

You can enjoy some culture when you stop by Blacks in Flight Mural in St. Louis. Experience the area's acclaimed theater scene and great live music.

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Payne-Gentry Historical House

7.0/10 (37 reviews)

Find out about the history of Bridgeton when you spend time at Payne-Gentry Historical House. Experience the acclaimed theater scene or attend a sporting event in this family-friendly area.

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Blanche M. Touhill Performing Arts Center

10.0/10 (2 reviews)

Enjoy an outing to Blanche M. Touhill Performing Arts Center during your stay in St. Louis. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.

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Old St. Ferdinand Shrine

2.0/10 (1 review)

You can spend time exploring the galleries in Old St. Ferdinand Shrine in Florissant. Experience the great live music and acclaimed theater scene in this family-friendly area.

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St. Louis Mercantile Library

St. Louis Mercantile Library is just one of the places to see in Normandy, so why not enjoy the other things to explore during your travels? Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.

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St. Louis Car Museum

9.2/10 (5 reviews)

You can spend time exploring the galleries in St. Louis Car Museum during your travels in Overland. Experience the great live music and acclaimed theater scene in this family-friendly area.

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St. Louis Kaplan Feldman Holocaust Museum

6.0/10 (1 review)

You can spend time studying the exhibits at St. Louis Kaplan Feldman Holocaust Museum during your travels in St. Louis. Experience the acclaimed theater scene and great live music in this family-friendly area.

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New Jewish Theatre

6.0/10 (1 review)

You can make plans for a show at New Jewish Theatre during your trip to St. Louis. Experience the acclaimed theater scene or attend a sporting event in this family-friendly area.

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Frequently asked questions

What's the area like around James S. McDonnell Prologue Room?

James S. McDonnell Prologue Room is located in a welcoming area of St. Louis known for its array of dining options and sporting events. You'll find 112 hotels and other accommodations within a few miles for a convenient home base.

What's the best hotel to stay close to James S. McDonnell Prologue Room?

Renaissance St. Louis Airport Hotel is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an indoor pool. It's located 1.2 mi (2 km) from James S. McDonnell Prologue Room. Other good choices within a few miles include Drury Inn & Suites St. Louis Airport and Pear Tree Inn St. Louis Airport.

How many hotels will I find near James S. McDonnell Prologue Room?

Expedia has 112 hotels and other accommodations a few miles from James S. McDonnell Prologue Room.

If I need to cancel the hotel reservation for my stay near James S. McDonnell Prologue Room, will I receive a refund?

Yes, most hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your arrival date. If you booked a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review the best options available near James S. McDonnell Prologue Room.

Where can I learn more about changing or cancelling my trip in the area near James S. McDonnell Prologue Room?

For more details about picking new dates or cancelling your stay near James S. McDonnell Prologue Room, go to https://www.expedia.com/service/.

What can I see and do near James S. McDonnell Prologue Room?

You'll want to browse the exhibits at Payne-Gentry Historical House and St. Louis Car Museum. Create some family memories at Par-Tee Recreation Center and Blanche M. Touhill Performing Arts Center. Old St. Ferdinand Shrine and St. Louis Mercantile Library are both worth a visit while you're checking out the area.

Find hotels near James S. McDonnell Prologue Room, St. Louis from ₩94,034

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Our top choices for James S. McDonnell Prologue Room hotels

1. Pear Tree Inn St. Louis Airport

2. Wingate by Wyndham St. Louis Airport

3. Hyatt Select St. Louis Airport

4. Drury Inn & Suites St. Louis Airport

5. Hampton Inn By Hilton St Louis Airport

6. Holiday Inn Express & Suites St Louis Airport by IHG

7. Renaissance St. Louis Airport Hotel

8. Marriott St. Louis Airport

9. DoubleTree by Hilton St. Louis Airport

10. Hilton St. Louis Airport

11. Quality Inn Florissant - St Louis

12. Travelodge by Wyndham St. Louis

13. HomeTowne Studios by Red Roof St. Louis - Airport/ N Lindbergh

14. Welcome Suites Hazelwood

15. Quality Inn Saint Louis Airport

16. Drury Plaza Hotel St. Louis St. Charles

17. The Knight Center at Washington University

18. Drury Plaza Hotel St. Louis Brentwood

19. Hampton Inn & Suites St. Louis at Forest Park

20. Clayton Plaza Hotel & Extended Stay

Compare popular hotels close to James S. McDonnell Prologue Room

Top James S. McDonnell Prologue Room Hotel Reviews

Holiday Inn Express & Suites St Louis Airport by IHG

Pear Tree Inn St. Louis Airport

La Quinta Inn & Suites by Wyndham St. Louis Hazelwood/ North

Travelodge by Wyndham St. Louis

Drury Inn & Suites St. Louis Airport

Renaissance St. Louis Airport Hotel

Quality Inn Florissant - St Louis

Hyatt Select St. Louis Airport

Hampton Inn By Hilton St Louis Airport

Other attractions near James S. McDonnell Prologue Room

Blacks in Flight Mural

Payne-Gentry Historical House

Blanche M. Touhill Performing Arts Center

Old St. Ferdinand Shrine

St. Louis Mercantile Library

St. Louis Car Museum

St. Louis Kaplan Feldman Holocaust Museum

New Jewish Theatre

Frequently asked questions