The Best Hotels Closest to James S. McDonnell Prologue Room in St. Louis for 2026

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Our top choices for James S. McDonnell Prologue Room hotels

A spacious lobby with modern seating, a reception desk, and large windows offering views of the parking area.

A seating area with three grey armchairs and a central glass-top table, a wooden floor, and a view of parked cars through large windows.

A spacious indoor area with multiple wooden tables and chairs, large windows, and a high ceiling with exposed beams.

A spacious indoor area with a high ceiling and large windows, featuring multiple seating areas with sofas and chairs, and a visible outdoor view through the windows.

1. Pear Tree Inn St. Louis Airport

2.6 km from James S. McDonnell Prologue Room

Murphy

₩121,853

₩143,467 total

includes taxes & fees

Oct 4 - Oct 5

A multi-level hotel lobby with seating areas, a reception desk, and large windows offering views.

A pool area with two hot tubs, seating, and a view of the outdoors.

A hotel reception area with a counter, seating, and a staircase.

A hotel room with a bed, two armchairs, a sofa, a small table, and a nightstand.

2. Drury Inn & Suites St. Louis Airport

2.1 km from James S. McDonnell Prologue Room

Lakeshia

₩155,705

₩182,700 total

includes taxes & fees

Oct 4 - Oct 5

A modern living room with a built-in fireplace, a large flat-screen TV, a unique hexagonal pendant light, and a patterned rug.

A modern dining area with a long table, multiple chairs, and a unique chandelier.

A modern lobby with blue seating, a reception desk, and large windows.

A multi-story hotel with a stone facade, a covered entrance, and a parking lot.

3. Hyatt Select St. Louis Airport

1.9 km from James S. McDonnell Prologue Room

Maxine

₩148,948

₩183,168 total

includes taxes & fees

Oct 8 - Oct 9

An indoor swimming pool with clear glass walls, blue lounge chairs, and a lifeguard stand.

A dining area with tables and chairs, a blue sofa, and a patterned carpet.

A hotel lobby with a reception desk, seating area, and a view of the parking lot.

A snack vending machine with various snack options.

4. Hampton Inn By Hilton St Louis Airport

2 km from James S. McDonnell Prologue Room

Leia

₩174,404

₩208,129 total

includes taxes & fees

Oct 8 - Oct 9

A breakfast buffet with labeled sections for fruit and cereal.

A Holiday Inn Express & Suites building with a covered entrance, a truck with the hotel branding, and a clear sky.

A coffee station with two coffee machines and a variety of coffee pods and cups.

A conference room with a long table, chairs, a projector screen, and a colorful carpet.

5. Holiday Inn Express & Suites St Louis Airport by IHG

2 km from James S. McDonnell Prologue Room

Keneace

₩165,197

₩202,569 total

includes taxes & fees

Oct 25 - Oct 26

A buffet with fruits, pastries, and beverages.

The Renaissance Hotel with a modern architectural design, featuring a prominent central entrance and a symmetrical facade.

A spacious hotel lobby with multiple seating areas, a reception desk, and large windows offering a view of the cityscape.

A modern bar area with a long counter, white bar stools, and a mix of bar and dining tables.

6. Renaissance St. Louis Airport Hotel

Berkeley, 2 km from James S. McDonnell Prologue Room

Anthony

₩159,983

₩187,161 total

includes taxes & fees

Oct 15 - Oct 16

A modern dining area with round tables, orange chairs, and a decorative wall with pottery.

A modern hotel lobby with a bar area, seating arrangements, and decorative lighting.

A swimming pool with a glass enclosure, a lounge area with orange chairs, and a view of a landscaped garden.

A modern lobby with seating areas, a reception desk, and a bar area.

7. Marriott St. Louis Airport

2.4 km from James S. McDonnell Prologue Room

Chris

₩201,418

₩240,368 total

includes taxes & fees

Oct 2 - Oct 3

A modern interior with a wooden panel wall, a kitchen area, and a dining space with pendant lighting.

A modern hotel with a prominent DoubleTree by Hilton sign, a well-lit entrance, and a landscaped front yard.

A modern kitchen with a marble countertop, red ceiling, and pendant lighting.

A hotel room with a large bed, a chair, a table, and a cityscape mural on the wall.

8. DoubleTree by Hilton St. Louis Airport

2.1 km from James S. McDonnell Prologue Room

Samone

₩154,337

₩181,095 total

includes taxes & fees

Oct 2 - Oct 3

A bar area with a long counter, multiple seating options, and a television screen displaying a program.

A spacious lobby with a reception desk, seating area, and a modern ceiling design.

A hotel lobby with a central seating area featuring sofas and tables, a large TV screen displaying a sports game, and a bar area with chairs and a counter.

A multi-story hotel with a central courtyard, surrounded by trees and a parking lot.

9. Hilton St. Louis Airport

1.9 km from James S. McDonnell Prologue Room

raymond

₩185,616

₩221,512 total

includes taxes & fees

Oct 2 - Oct 3

A hotel dining area with multiple tables and chairs, a sofa, and a large window with curtains.

A hotel with a beige facade, a clear sign reading "Quality Inn," and a parking lot with a red car.

A hotel room with two beds, a desk with a lamp, a television, and a painting on the wall.

A workspace with two desks, two computers, a clock, and a framed picture on the wall.

10. Quality Inn Florissant - St Louis

3.1 km from James S. McDonnell Prologue Room

Sharonda

₩90,926

₩107,384 total

includes taxes & fees

Oct 19 - Oct 20

A parking lot with multiple cars, a building with a green and beige facade, and a sign for Home Towne Studios.

A compact kitchenette with a sink, stove, microwave, and a white refrigerator.

A hotel room with a bed, a desk, a chair, a flat-screen TV, and a wooden floor.

11. HomeTowne Studios by Red Roof St. Louis - Airport/ N Lindbergh

2.9 km from James S. McDonnell Prologue Room

Kimberly

₩94,785

₩115,863 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with a large bed, bedside tables, a heater, and a view of the city.

A multi-story brick building with a central entrance, parking lot, and designated handicapped parking spaces.

A stairwell with a metal railing, a trash can, and a window with a view of trees.

A modern living room with a grey sofa, a red bench, a dark wooden table, and a TV on a stand.

12. Welcome Suites Hazelwood

3 km from James S. McDonnell Prologue Room

Arutyun

₩101,555

₩124,140 total

includes taxes & fees

Sep 29 - Sep 30

A hotel room with a bed, bedside table, lamp, TV, and a desk with a chair.

A kitchen with a built-in refrigerator, a coffee maker, and a microwave. There are cabinets and a countertop with various items on it.

A spacious dining area with multiple tables and chairs, a kitchen area with dark cabinets, and a flat-screen TV mounted on the wall.

A spacious lobby with a patterned tile floor, a staircase, and seating areas.

13. Quality Inn Saint Louis Airport

2 km from James S. McDonnell Prologue Room

Gordon

₩82,503

₩101,342 total

includes taxes & fees

Oct 25 - Oct 26

A modern lobby with orange seating, a flat-screen TV, and a stone accent wall.

A gym with treadmills, stationary bikes, and a weight machine.

A hotel pool area with a hot tub, lounge chairs, and a 'No Diving Allowed' sign.

A hotel room with two beds, a headboard, bedside lamps, a clock, and a window with curtains.

14. Drury Plaza Hotel St. Louis St. Charles

12.8 km from James S. McDonnell Prologue Room

Robert

₩196,327

₩227,597 total

includes taxes & fees

Oct 4 - Oct 5

A restaurant with round tables and chairs, a bar area, and a patterned ceiling.

A lobby with a reception desk, seating area with sofas and ottomans, and a patterned rug.

A Drury Plaza Hotel with a large parking lot and multiple cars parked in front.

A spa bath with a sign indicating a capacity of 8 persons.

15. Drury Plaza Hotel St. Louis Brentwood

13.6 km from James S. McDonnell Prologue Room

Janell

₩184,140

₩218,616 total

includes taxes & fees

Oct 4 - Oct 5

An indoor swimming pool with lounge chairs and a pool table, surrounded by large windows.

A spacious room with a long table and chairs, a television mounted on the wall, and a 'Welcome to the Show Nest' sign.

A hotel with a modern design, featuring a large entrance, multiple floors, and a parking lot.

A snack and treat display with various products, including chips and beverages, in a store setting.

16. Hampton Inn & Suites St. Louis at Forest Park

Dogtown, 14.4 km from James S. McDonnell Prologue Room

Jennifer

₩187,647

₩221,289 total

includes taxes & fees

Oct 5 - Oct 6

An outdoor patio with a fire pit, seating, and a building in the background.

A modern hotel lobby with a bar area, a large dining table, and a seating area with chairs.

A modern bar area with a wooden counter, a beverage dispenser, and a menu board.

A Courtyard by Marriott hotel with a modern facade, multiple floors, and a well-lit entrance.

17. Courtyard by Marriott St. Louis Brentwood

13.5 km from James S. McDonnell Prologue Room

Aaron

₩159,983

₩195,131 total

includes taxes & fees

Oct 11 - Oct 12

A courtyard with outdoor seating, a central fountain, and a view of a tower.

A buffet setup with various food items, a coffee station, and a refrigerator with beverages.

A spacious lobby with a bar area, seating arrangements, and a clock on the wall.

A hotel room with two beds, a desk, and a chair.

18. The Knight Center at Washington University

11.4 km from James S. McDonnell Prologue Room

Kenney

₩229,041

₩263,370 total

includes taxes & fees

Oct 4 - Oct 5

A brick building with a sign reading "Country Inn & Suites."

A spacious living room with a blue sofa, a white coffee table, and a striped armchair. There is a bookshelf filled with decorative items and a television on a wooden stand.

A spacious living room with a large window, a wooden bookshelf, a green sofa, and a coffee table.

An indoor swimming pool with a tiled floor, a central window, and multiple chairs around the pool.

19. Country Inn & Suites by Radisson, St. Charles Historic District

12.5 km from James S. McDonnell Prologue Room

Roseanna

₩192,792

₩221,570 total

includes taxes & fees

Oct 12 - Oct 13

A multi-story building with a grand entrance, large windows, and a well-lit facade at night.

A dining room with two tables, chairs, a chandelier, and a fireplace.

A wooden table set for a meal under a tent with string lights, surrounded by chairs on a grassy area.

A hotel room with a four-poster bed, a dining table with chairs, a bedside table with lamps, and a floral-patterned rug.

20. Grand Center Inn

15.5 km from James S. McDonnell Prologue Room

Leon and Janis

₩242,379

₩285,835 total

includes taxes & fees

Oct 1 - Oct 2

View all properties

Compare popular hotels close to James S. McDonnell Prologue Room

Property	Property class	Guest rating
Pear Tree Inn St. Louis Airport	9.2 Wonderful 3,270 reviews	View
Drury Inn & Suites St. Louis Airport	9.2 Wonderful 1,428 reviews	View
Hyatt Select St. Louis Airport	9.2 Wonderful 1,008 reviews	View
Hampton Inn By Hilton St Louis Airport	9.0 Wonderful 228 reviews	View
Holiday Inn Express & Suites St Louis Airport by IHG	8.6 Excellent 1,002 reviews	View

Top James S. McDonnell Prologue Room Hotel Reviews

Hampton Inn By Hilton St Louis Airport

8/10 Good

"Breakfast was not the greatest. Sausage patties whose edges were over microwaved. Diced potatoes was almost out. Omelettes were out. Apple juice ran out. Worker need to check and restock more often. It was only 8:30am. Worker only returned chairs to table but not bother to clean trash from table. Unimpressive. Everything else about the hotel was great. Probably should have walked over to connected Hilton for breakfast."

Hyatt Select St. Louis Airport

10/10 Excellent

"Clean room, kind staff, and a really solid breakfast!"

Renaissance St. Louis Airport Hotel

10/10 Excellent

"Staff was great! Would come back to stay."

Holiday Inn Express & Suites St Louis Airport by IHG

10/10 Excellent

"Every thing was perfect. The staff was VERY attentive, rooms were very comfortable, the bed was the most comfortable and the breakfast was more than enough. Absolutely would stay here again."

Hilton St. Louis Airport

10/10 Excellent

"Service"

Comfort Inn & Suites Hazelwood - St. Louis

10/10 Excellent

"Best time ever"

Other attractions near James S. McDonnell Prologue Room

Blacks in Flight Mural

You can enjoy some culture when you stop by Blacks in Flight Mural in St. Louis. Experience the area's fascinating museums and acclaimed art scene.

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Payne-Gentry Historical House

7.0/10 (37 reviews)

Find out about the history of Bridgeton when you spend time at Payne-Gentry Historical House. Experience the acclaimed theater scene or attend a sporting event in this family-friendly area.

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Blanche M. Touhill Performing Arts Center

10.0/10 (2 reviews)

Enjoy an outing to Blanche M. Touhill Performing Arts Center during your stay in St. Louis. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.

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Old St. Ferdinand Shrine

2.0/10 (1 review)

You can spend time exploring the galleries in Old St. Ferdinand Shrine in Florissant. Experience the great live music and acclaimed theater scene in this family-friendly area.

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St. Louis Mercantile Library

St. Louis Mercantile Library is just one of the places to see in Normandy, so why not enjoy the other things to explore during your travels? Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.

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St. Louis Car Museum

9.2/10 (5 reviews)

You can spend time exploring the galleries in St. Louis Car Museum during your travels in Overland. Experience the acclaimed theater scene and great live music in this family-friendly area.

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St. Louis Kaplan Feldman Holocaust Museum

6.0/10 (1 review)

You can spend time studying the exhibits at St. Louis Kaplan Feldman Holocaust Museum during your travels in St. Louis. Experience the great live music and acclaimed theater scene in this family-friendly area.

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New Jewish Theatre

6.0/10 (1 review)

You can make plans for a show at New Jewish Theatre during your trip to St. Louis. Experience the acclaimed theater scene or attend a sporting event in this family-friendly area.

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Frequently asked questions

What's the area like around James S. McDonnell Prologue Room?

James S. McDonnell Prologue Room is located in a welcoming area of St. Louis known for its array of dining options and sporting events. You'll find 116 hotels and other accommodations within a few miles for a convenient home base.

What's the best hotel to stay close to James S. McDonnell Prologue Room?

Renaissance St. Louis Airport Hotel is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an indoor pool. It's located 1.2 mi (2 km) from James S. McDonnell Prologue Room. Other good choices within a few miles include Pear Tree Inn St. Louis Airport and Drury Inn & Suites St. Louis Airport.

How many hotels will I find near James S. McDonnell Prologue Room?

Expedia has 116 hotels and other accommodations a few miles from James S. McDonnell Prologue Room.

If I need to cancel the hotel reservation for my stay near James S. McDonnell Prologue Room, will I receive a refund?

Yes, most hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your arrival date. If you booked a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review the best options available near James S. McDonnell Prologue Room.

Where can I learn more about changing or cancelling my trip in the area near James S. McDonnell Prologue Room?

For more details about picking new dates or cancelling your stay near James S. McDonnell Prologue Room, go to https://www.expedia.com/service/.

What can I see and do near James S. McDonnell Prologue Room?

You'll want to browse the exhibits at Payne-Gentry Historical House and St. Louis Car Museum. Create some family memories at Par-Tee Recreation Center and Blanche M. Touhill Performing Arts Center. Old St. Ferdinand Shrine and St. Louis Mercantile Library are both worth a visit while you're checking out the area.

Find hotels near James S. McDonnell Prologue Room, St. Louis from ₩101,342

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Treat yourself

Be picky

Check prices for these dates

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Our top choices for James S. McDonnell Prologue Room hotels

1. Pear Tree Inn St. Louis Airport

2. Drury Inn & Suites St. Louis Airport

3. Hyatt Select St. Louis Airport

4. Hampton Inn By Hilton St Louis Airport

5. Holiday Inn Express & Suites St Louis Airport by IHG

6. Renaissance St. Louis Airport Hotel

7. Marriott St. Louis Airport

8. DoubleTree by Hilton St. Louis Airport

9. Hilton St. Louis Airport

10. Quality Inn Florissant - St Louis

11. HomeTowne Studios by Red Roof St. Louis - Airport/ N Lindbergh

12. Welcome Suites Hazelwood

13. Quality Inn Saint Louis Airport

14. Drury Plaza Hotel St. Louis St. Charles

15. Drury Plaza Hotel St. Louis Brentwood

16. Hampton Inn & Suites St. Louis at Forest Park

17. Courtyard by Marriott St. Louis Brentwood

18. The Knight Center at Washington University

19. Country Inn & Suites by Radisson, St. Charles Historic District

20. Grand Center Inn

Compare popular hotels close to James S. McDonnell Prologue Room

Top James S. McDonnell Prologue Room Hotel Reviews

Hampton Inn By Hilton St Louis Airport

Hyatt Select St. Louis Airport

Renaissance St. Louis Airport Hotel

Holiday Inn Express & Suites St Louis Airport by IHG

Hilton St. Louis Airport

Comfort Inn & Suites Hazelwood - St. Louis

Other attractions near James S. McDonnell Prologue Room

Blacks in Flight Mural

Payne-Gentry Historical House

Blanche M. Touhill Performing Arts Center

Old St. Ferdinand Shrine

St. Louis Mercantile Library

St. Louis Car Museum

St. Louis Kaplan Feldman Holocaust Museum

New Jewish Theatre

Frequently asked questions