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Find Resorts & Hotels with Spas in Central San Diego, CA

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Check availability on Central San Diego Resorts & Hotels with Spas

Tonight
Sep 30 - Oct 1
Tomorrow
Oct 1 - Oct 2
This weekend
Oct 2 - Oct 4
Next weekend
Oct 9 - Oct 11

Our top choices for Central San Diego hotels with a spa

A modern bathroom with a shower, a towel rack, and a bench.
A pathway leading to a building labeled "LEGACY Hotel."
A spacious lobby with modern furniture, large windows, and a high ceiling with hanging lights.
A hotel room with a large bed, a wooden nightstand, a bench, a desk with a TV, and a chair.

1. Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa
Mission Valley
  • Indulge in a serene escape at this upscale hotel with a full-service spa, outdoor pool with free cabanas, and couples massage treatments.
₩234,416
₩269,444 total
includes taxes & fees
Oct 4 - Oct 5
Legacy Resort Hotel & Spa
A hotel with a curved entrance, palm trees, and a parking lot.
A spacious lobby with a central round table, a reception desk, and a bar area.
A bar area with wooden chairs and tables, a bar counter with various bottles, and a sign reading "BEACH BUMS CATER HERE".
A lobby with seating areas, a piano, and a reception desk.

2. Handlery Hotel

Handlery Hotel
Mission Valley
  • Surrender to spa treatments and poolside luxury at this hotel with massage rooms and a beautiful heated outdoor pool and hot tub.
₩139,732
₩160,615 total
includes taxes & fees
Oct 5 - Oct 6
Handlery Hotel
An aerial view of a resort with a central swimming pool, palm trees, and a view of the ocean and beach.
A living room with a fireplace, a television, a sofa, a chair, a round coffee table, and a view of the ocean through glass doors.
A modern building with a curved roof, surrounded by lush tropical vegetation.
An outdoor dining area with tables and chairs, umbrellas, and string lights against a sunset backdrop.

3. Paradise Point Resort & Spa

Paradise Point Resort & Spa
Mission Bay
  • Immerse in waterfront tranquility with hot stone massages and aromatherapy at this resort spa retreat.
₩240,130
₩347,677 total
includes taxes & fees
Oct 30 - Oct 31
Paradise Point Resort & Spa
A spa room with a bed, a bathtub, and a large window with curtains. There are candles and plants on the windowsill.
A modern dining area with a glass table, candles, and wicker chairs.
A poolside view with a lounge chair, a towel, a tray with a drink and a coconut, and a pool with palm trees in the background.
An outdoor seating area with a canopy, lounge chairs, and a fire pit.

4. San Diego Mission Bay Resort

San Diego Mission Bay Resort
Mission Bay
  • Unwind at this bay-view resort offering garden massages, poolside lounging, and a rejuvenating full-service spa retreat.
₩270,143
₩382,300 total
includes taxes & fees
Oct 31 - Nov 1
San Diego Mission Bay Resort
A person sitting by a pool with a tiled floor and a marble wall.
A modern hotel with a prominent entrance, multiple floors, and a landscaped area with palm trees and a bridge.
A modern lounge area with dark-toned seating, a central coffee table, and a stone accent wall.
A modern lounge area with leather seating, a central fire feature, and geometric patterned railings.

5. Sycuan Casino Resort

Sycuan Casino Resort
El Cajon
  • Escape to a luxurious mountain retreat with 10 treatment rooms and outdoor pools, where hot stone massages and aromatherapy await.
₩118,102
₩146,202 total
includes taxes & fees
Oct 15 - Oct 16
Sycuan Casino Resort
A spacious lobby with a reception desk, seating area, and a stone wall.
A canal lined with palm trees and a row of buildings with balconies.
A marina with wooden tables and chairs, umbrellas, and a view of boats and city lights in the background.
A resort with two-story buildings, balconies, and a pool area.

6. Humphreys Half Moon Inn

Humphreys Half Moon Inn
Point Loma
  • Escape to this bayfront sanctuary with deep-tissue massages, a serene hot tub, and an outdoor pool for complete relaxation.
₩229,418
₩290,858 total
includes taxes & fees
Oct 25 - Oct 26
Humphreys Half Moon Inn
A hotel room with a large bed, a desk, a chair, a painting, and a view of the city.
A swimming pool with lounge chairs and umbrellas, surrounded by palm trees and greenery.
A hotel entrance with a covered walkway, palm trees, and a parking area.
A spacious lobby with a round table, blue benches, a large painting, and a view of the outdoors.

7. Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
National City
  • Indulge in bay-side spa services and hot tub relaxation at this tranquil hotel where pampering treatments meet scenic marina views.
₩202,268
₩222,888 total
includes taxes & fees
Oct 4 - Oct 5
Best Western Plus Marina Gateway Hotel
A spacious lobby with a reception desk, seating area, and artwork on the walls.
A marina with boats docked, a covered outdoor dining area with red chairs and tables, and a view of the marina in the background.
A resort pool with a lazy river, palm trees, and a view of the ocean.
A hotel entrance with a covered walkway, palm trees, and a modern building in the background.

8. Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina
Mission Bay
  • Experience coastal tranquility at this spa hotel with bay views, heated pools, and waterslides.
₩283,718
₩397,951 total
includes taxes & fees
Nov 1 - Nov 2
Hyatt Regency Mission Bay Spa and Marina
A woman in a floral swimsuit stepping out of a spa area with a hot tub, a lounge chair, and a sign indicating an outdoor terrace.
A couple dining outdoors at a table with a fire feature, in front of a classical building with arches.
A resort with a large swimming pool, multiple buildings, and surrounding greenery.
A pool area with lounge chairs and umbrellas, surrounded by palm trees and stone columns.

9. Fairmont Grand Del Mar

Fairmont Grand Del Mar
Carmel Valley
  • Escape to a Mediterranean spa sanctuary with 11 luxurious treatment rooms and four outdoor pools for ultimate rejuvenation.
₩948,893
₩1,200,617 total
includes taxes & fees
Nov 1 - Nov 2
Fairmont Grand Del Mar
A dining area with a checkered floor, wooden chairs, a marble table, and a view of tropical foliage through large windows.
A room with a large glass door leading to a grassy deck with a table and chairs, overlooking a marina with boats and a clear sky.
A couple walking through a wooden door into a building with a tropical garden view.
An outdoor patio with seating, a fire pit, and a view of the ocean.

10. Catamaran Resort and Spa

Catamaran Resort and Spa
Mission Beach
  • Luxurious beachside retreat offers 10 spa treatment rooms, waterfront yoga, and a serene bay location for ultimate wellness.
₩270,414
₩383,048 total
includes taxes & fees
Nov 1 - Nov 2
Catamaran Resort and Spa
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Choose what matters most at spa hotels in Central San Diego

Pool
Breakfast included
Hot tub
4 stars
5 stars

Top Central San Diego Hotel Reviews

Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley

8/10 Good
"Hotel was very decent and clean. Staff were very good. Furnishing outdated and worned. Needs updated face-lift. I would, however, stay there again."
Sharon 4-night trip
Posted less than an hour ago
Hampton Inn San Diego/Mission Valley
Hilton San Diego Mission Valley

Hilton San Diego Mission Valley

10/10 Excellent
"It was top tier all around."
Jesus 2-night trip
Posted 2 hours ago
Hilton San Diego Mission Valley
California Suites Hotel

California Suites Hotel

8/10 Good
"Clean centrally located. Friendly staff."
Craig 1-night trip
Posted 3 hours ago
California Suites Hotel
Handlery Hotel

Handlery Hotel

10/10 Excellent
"Nice hotel. Would recommend"
Kelsey 4-night trip
Posted 5 hours ago
Handlery Hotel
The Alcala Hotel Mission Valley/Seaworld

The Alcala Hotel Mission Valley/Seaworld

10/10 Excellent
"Hot breakfast and cold breakfast. Along with juice and coffee. 6-9am Access to the pool and Jacuzzi. Small but clean rooms Super helpful and friendly staff Basically everything you would want for a budget stay"
Rebecca 1-night trip
Posted 9 hours ago
The Alcala Hotel Mission Valley/Seaworld

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