Panama City Vacations
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to ₩234,741 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Where to stay in Panama City
Find the best Panama City areas and neighborhoods for the activities you enjoy most. Learn more about Panama City
Casco Viejo
4.5/5(178 area reviews)
Unique features of Casco Viejo include the historic sites and bars. Make a stop by Interoceanic Canal Museum or National Theater while you're exploring the area.
Find the Best Panama City Vacation Packages
Panama City Hotel Deals
Hotel Riu Plaza Panama
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
The price is ₩178,680 per night from Jan 18 to Jan 19
₩178,680
₩196,548 total
Jan 18 - Jan 19
includes taxes & fees
9/10 Wonderful! (4,808 reviews)
Nice room and accommodations
Reviewed on Jan 6, 2026
Las Americas Golden Tower Panama
Av. Balboa con Calle 53 Panama City Panama
Fully refundableReserve now, pay when you stay
The price is ₩216,940 per night from Jan 31 to Feb 1
₩216,940
₩238,637 total
Jan 31 - Feb 1
includes taxes & fees
8.8/10 Excellent! (1,022 reviews)
Going location, great city views
Reviewed on Jan 4, 2026
Waldorf Astoria Panama
47th St. & Uruguay Street Panama City Panama
Fully refundableReserve now, pay when you stay
The price is ₩321,850 per night from Jan 30 to Jan 31
₩321,850
₩354,035 total
Jan 30 - Jan 31
includes taxes & fees
8.8/10 Excellent! (1,004 reviews)
awesome location, great staff
Reviewed on Jan 12, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Panama City
Multiplaza Pacific Mall
During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.
Uruguay Street
During your visit to Panama City, you can do some window-shopping at Uruguay Street. While in this family-friendly area, you can savor the top-notch restaurants.
Amador Causeway
You can learn about the history of Ancon with a stop at Amador Causeway. Stroll along the seaside or visit the shops in this vibrant area.
Explore a world of travel with Expedia
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
