Panama City Vacations

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Where to stay in Panama City

Find the best Panama City areas and neighborhoods for the activities you enjoy most. Learn more about Panama City
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Casco Viejo

4.5/5(178 area reviews)

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Interoceanic Canal Museum or National Theater while you're exploring the area.

Find hotels in Casco Viejo

Find the Best Panama City Vacation Packages

Panama City Hotel Deals

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is ₩184,815 per night from Nov 10 to Nov 11
₩184,815
₩203,296 total
Nov 10 - Nov 11
includes taxes & fees
9/10 Wonderful! (4,482 reviews)
Wonderfull

Reviewed on Nov 5, 2025

Hotel Riu Plaza Panama
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa, Panama City
Fully refundableReserve now, pay when you stay
The price is ₩186,074 per night from Nov 28 to Nov 29
₩186,074
₩204,681 total
Nov 28 - Nov 29
includes taxes & fees
8.4/10 Very Good! (1,174 reviews)
Room was excellent

Reviewed on Nov 2, 2025

Megapolis Hotel Panamá
Waldorf Astoria Panama

Waldorf Astoria Panama

5 out of 5
47th St. & Uruguay Street, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is ₩247,169 per night from Dec 6 to Dec 7
₩247,169
₩271,886 total
Dec 6 - Dec 7
includes taxes & fees
8.8/10 Excellent! (1,000 reviews)
Upon arrival to the Waldorf, Edgar was right there to assist us with our luggage to the room. It was at that moment I knew the W.A. hospitality was about to be extraordinary.

Reviewed on Oct 22, 2025

Waldorf Astoria Panama
See all 1,486 properties in Panama City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Panama City

Rainy day in Panama City but the charm of this city never ends. A beautiful rainbow over the city invites us to spend a bright day in paradise. #LifeAtExpedia

Multiplaza Pacific Mall

4.5/5(634 reviews)

During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.

Multiplaza Pacific Mall
Panama City skyline during the day #seetheworld

Uruguay Street

4/5(59 reviews)

During your visit to Panama City, you can do some window-shopping at Uruguay Street. While in this family-friendly area, you can savor the top-notch restaurants.

Uruguay Street
UNESCO site, Casco Viejo

Metropolitan Cathedral of Panama

4.5/5(423 reviews)

Metropolitan Cathedral of Panama is just one of the places to see in Panama City, so why not enjoy the other things to explore during your travels? Check out the shops and top-notch restaurants in this vibrant area.

Metropolitan Cathedral of Panama
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