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Our top choices for Santa Clara hotels

Outdoor pool, pool umbrellas, sun loungers
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG
4.0 star property
10.2 km from Santa Clara
8.4 out of 10, Very Good, (2327)
"Spacious room, clean, good breakfast "
United States
Juan
The price is ₩162,524
₩178,776 total
includes taxes & fees
Dec 25 - Dec 26
Crowne Plaza Panama Airport by IHG
Living area
ORHO HOTEL BOUTIQUE PANAMA Airport

ORHO HOTEL BOUTIQUE PANAMA Airport

ORHO HOTEL BOUTIQUE PANAMA Airport
2.5 star property
9.7 km from Santa Clara
9.0 out of 10, Wonderful, (38)
"It was a cool unique antique place that had modern touches. The staff was very friendly and helpful. Will definitely stay again. "
United States
Clarissa
The price is ₩177,299
₩230,134 total
includes taxes & fees
Jan 5 - Jan 6, 2026
ORHO HOTEL BOUTIQUE PANAMA Airport
Outdoor pool, open 7:00 AM to 10:30 PM, free cabanas, pool umbrellas
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino
4.0 star property
8.7 km from Santa Clara
8.6 out of 10, Excellent, (1854)
"The room was impeccable, staff was awesome and very professional!!!"
United States
Scott
The price is ₩184,760
₩203,236 total
includes taxes & fees
Dec 24 - Dec 25
Riande Aeropuerto Hotel & Casino
Outdoor pool, sun loungers
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
5.0 star property
Campo Alegre, 8 km from Santa Clara
9.0 out of 10, Wonderful, (4711)
"Awesome great place to stay "
United States
Herbert
The price is ₩161,576
₩177,734 total
includes taxes & fees
Jan 12 - Jan 13, 2026
Hotel Riu Plaza Panama
Suite, 1 Bedroom, Golf View (Terrace) | Premium bedding, minibar, in-room safe, desk
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
5.0 star property
Juan Diaz, 2.8 km from Santa Clara
9.6 out of 10, Exceptional, (642)
"As usual the stay was amazing in this hotel"
United States
Jose
The price is ₩331,327
₩364,467 total
includes taxes & fees
Jan 23 - Jan 24, 2026
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
2 outdoor pools, pool umbrellas, sun loungers
Radisson Hotel Panama Canal

Radisson Hotel Panama Canal

Radisson Hotel Panama Canal
4.5 star property
Amador, 13.9 km from Santa Clara
8.4 out of 10, Very Good, (1004)
"Wonderful staff and easy checkin!"
United States
Kristin
The price is ₩123,075
₩135,382 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Radisson Hotel Panama Canal
Outdoor pool, pool umbrellas, sun loungers
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica
4.0 star property
San Francisco, 6.6 km from Santa Clara
9.6 out of 10, Exceptional, (1123)
"The hotel is in a great location in Panama. Great amenities excellent breakfast."
United States
Maria
The price is ₩144,676
₩159,141 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Ramada Plaza by Wyndham Panama Punta Pacifica
Breakfast, lunch, dinner served; international cuisine
Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall
4.0 star property
3.2 km from Santa Clara
8.8 out of 10, Excellent, (1002)
"The hotel is conveniently close to the airport and shopping centres. "
United States
Samantha
The price is ₩149,448
₩164,393 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Courtyard by Marriott Panama Metromall
Exterior
Hotel Milan

Hotel Milan

Hotel Milan
3.0 star property
El Cangrejo, 8.2 km from Santa Clara
9.0 out of 10, Wonderful, (429)
"It was a very pleasant experience the hotel is located in a great neighborhood, staff were friendly and competent, secure property and parking, clean and decent accommodations, especially at the room price point. "
Canada
Roger
The price is ₩59,100
₩65,010 total
includes taxes & fees
Dec 25 - Dec 26
Hotel Milan
50-inch LED TV with satellite channels
Arcadia Condo Suites

Arcadia Condo Suites

Arcadia Condo Suites
2.5 star property
Costa del Este, 2.8 km from Santa Clara
9.4 out of 10, Exceptional, (164)
"Everything was great, helpful staff, great room , clean, excellent service!"
United States
Gregory Walter
The price is ₩104,902
₩183,652 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Arcadia Condo Suites
Front of property - evening/night
Principe Hotel and Suites

Principe Hotel and Suites

Principe Hotel and Suites
3.0 star property
El Cangrejo, 7.8 km from Santa Clara
9.0 out of 10, Wonderful, (1611)
"Friendly staff. "
United States
Thessely
The price is ₩75,351
₩82,886 total
includes taxes & fees
Dec 24 - Dec 25
Principe Hotel and Suites
Front of property
Megapolis Hotel Panamá

Megapolis Hotel Panamá

Megapolis Hotel Panamá
4.5 star property
Punta Paitilla, 8.2 km from Santa Clara
8.4 out of 10, Very Good, (1300)
"Clean rooms, staff was amazing!!"
United States
Christopher
The price is ₩345,054
₩379,559 total
includes taxes & fees
Dec 25 - Dec 26
Megapolis Hotel Panamá
2 bars/lounges, gastropub
Riande Urban Hotel

Riande Urban Hotel

Riande Urban Hotel
3.5 star property
El Cangrejo, 7.9 km from Santa Clara
8.8 out of 10, Excellent, (1056)
"Good hotel and nice staff"
United States
Jose
The price is ₩124,264
₩136,690 total
includes taxes & fees
Dec 24 - Dec 25
Riande Urban Hotel
Restaurant
Hyatt Regency Panama City

Hyatt Regency Panama City

Hyatt Regency Panama City
4.5 star property
Campo Alegre, 8.4 km from Santa Clara
10.0 out of 10, Exceptional, (128)
"Great hotel fair price"
United States
Santiago
The price is ₩231,596
₩254,756 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hyatt Regency Panama City
View from property
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

Las Americas Golden Tower Panama
4.0 star property
Punta Paitilla, 8 km from Santa Clara
9.0 out of 10, Wonderful, (1006)
"I loved my stay! "
United States
Jenniffer Gonzalez De La
The price is ₩231,877
₩255,059 total
includes taxes & fees
Jan 22 - Jan 23, 2026
Las Americas Golden Tower Panama
View from property
Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel
3.5 star property
Punta Paitilla, 8.4 km from Santa Clara
9.4 out of 10, Exceptional, (2139)
"Great location of the hotel with a lovely breakfast and friendly staff"
United States
fouad
The price is ₩233,610
₩256,971 total
includes taxes & fees
Dec 30 - Dec 31
Plaza Paitilla Inn Hotel
Front of property
MARINN Tropical Vibes Hotel

MARINN Tropical Vibes Hotel

MARINN Tropical Vibes Hotel
3.5 star property
Amador, 14.8 km from Santa Clara
8.2 out of 10, Very Good, (193)
"Perfect location, nice rooms, nice views"
United States
Ever
The price is ₩132,974
₩146,271 total
includes taxes & fees
Dec 29 - Dec 30
MARINN Tropical Vibes Hotel
Meeting facility
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
4.5 star property
Obarrio, 7.5 km from Santa Clara
8.8 out of 10, Excellent, (1001)
"Everything was clean and the staff was very cooperative."
United States
Deangelo
The price is ₩234,921
₩258,413 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
View from room
The Beach House

The Beach House

The Beach House
3.0 star property
Amador, 15 km from Santa Clara
8.4 out of 10, Very Good, (408)
"Fantastic location on Amador Causeway and access to paddleboarding, restaurants, nightlife and family friendly events. One cool sloth in the tree overhanging the walkway at the Culebra nature area right by the prroperty."
United States
Cynthia
The Beach House
Exterior
AC Hotel by Marriott Panama City

AC Hotel by Marriott Panama City

AC Hotel by Marriott Panama City
3.5 star property
Campo Alegre, 8.2 km from Santa Clara
8.8 out of 10, Excellent, (744)
"The hotel is great, the room is clean and the rooftop pool is an added touch. Checkin was a breeze. The staff are very friendly and helpful and the hotel restaurant has excellent food."
Canada
Jayne
The price is ₩149,448
₩164,392 total
includes taxes & fees
Jan 9 - Jan 10, 2026
AC Hotel by Marriott Panama City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Santa Clara

Find the best Santa Clara areas and neighborhoods for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Interoceanic Canal Museum or National Theater while you're exploring the area.

Bella Vista

Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Crown Casino. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina.

El Cangrejo

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

Punta Paitilla

Travelers come to Punta Paitilla for its abundant dining options, and you can see top attractions like Avenida Balboa and Multicentro Panama while you're in town.

Top Santa Clara Hotel Reviews

Principe Hotel and Suites

Principe Hotel and Suites

10/10 Excellent
"Clean rooms, courteous staff. The front desk team is awesome. 2nd time visiting, i'll definitely be back!"
Janelle 8-night trip
Posted 2 days ago
Principe Hotel and Suites

Frequently asked questions

What is Santa Clara like?
Travelers will be sure to find plenty to entertain them in Panama City's Santa Clara neighborhood.
If I need to cancel my hotel reservation in Santa Clara, will I receive a refund?
Yes! You'll find that most hotel reservations are refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within 24 hours of your booking. Enter your dates, click on "Search", then filter by "fully refundable" to review the best options available in Santa Clara.
Where can I learn more about changing or cancelling my trip to Santa Clara?
To access more information about picking new dates or cancelling your trip to Santa Clara, go to https://www.expedia.com/service/.
What are the top things to see and do in Santa Clara?
A few places to visit in the area around Santa Clara include Estadio Rommel Fernandez, Plaza de Francia, and Atrio Mall. While you're out sightseeing, Monte Oscuro and Los Pueblos Commercial Center are a couple of additional sights to visit in Panama City.