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Discover 1,722 Clayton hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

The Ritz-Carlton, St. Louis
The Ritz-Carlton, St. Louis

Residence Inn By Marriott St. Louis Clayton
Residence Inn By Marriott St. Louis Clayton

Seven Gables, St. Louis West, a Tribute Portfolio Hotel
Seven Gables, St. Louis West, a Tribute Portfolio Hotel

Clayton Plaza Hotel & Extended Stay
Clayton Plaza Hotel & Extended Stay

AC Hotel St. Louis Clayton
AC Hotel St. Louis Clayton

Hampton Inn & Suites Clayton/St. Louis-Galleria Area
Hampton Inn & Suites Clayton/St. Louis-Galleria Area
Where to stay in Clayton

Downtown St. Louis
Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.
Creve Coeur
Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Saint Louis Abbey while you're in town.

Central West End
Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

Downtown West
If you're spending some time in Downtown West, St. Louis Union Station and St. Louis Aquarium at Union Station are top sights worth seeing.

Soulard
Brewery tours, a farmers market, global restaurants, blues bars and a Mardi Gras parade make this one of the city’s liveliest neighborhoods.
Recent reviews of Clayton hotels
Recent reviews of Clayton hotels

Moonrise Hotel
Explore a world of travel with Expedia
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